7277-86-3

Basic information

• Product Name: N-butyl-2-methylaniline
• Synonyms: N-butyl-2-methylaniline;N-Butyl-2-methylbenzenamine;N-Butyl-o-toluidine
• CAS NO: 7277-86-3
• Molecular Formula: C₁₁H₁₇N
• Molecular Weight: 163.26
• Mol File: 7277-86-3.mol
• Article Data: 24

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-butyl-2-methylaniline(CAS DataBase Reference)
• NIST Chemistry Reference: N-butyl-2-methylaniline(7277-86-3)
• EPA Substance Registry System: N-butyl-2-methylaniline(7277-86-3)

Safety Data

• Hazardous Substances Data: 7277-86-3(Hazardous Substances Data)

Upstream product

• 542-69-8 1-iodo-butane 
• 95-53-4 o-toluidine 
• 109-69-3 n-Butyl chloride 
• 142-96-1 dibutyl ether 
• 636-21-5 o-toluidine hydrochloride 
• 71-36-3 butan-1-ol 
• 66107-34-4 2-methylphenyl triflate 
• 109-73-9 N-butylamine 
• 109-65-9 1-bromo-butane 
• 95-49-8 2-methylchlorobenzene 
• 102-82-9 tributyl-amine 
• 1643-19-2 tetrabutylammomium bromide 
• 109-72-8 n-butyllithium 
• 140244-82-2 (Z)-(2-methylphenyl)azo tert-butyl sulfide 

Downstream Products

• 82749-64-2 N,N-dibutyl-2-methylaniline 
• 1307740-86-8 2-(4-butylamino-3-methylphenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol 
• 1307741-01-0 N-butyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2-methylphenyl]-2-iodobenzamide 
• 861519-10-0 N-butyl-2-methyl-4-nitroso-aniline 
• 64062-64-2 3-(2-Methoxy-aethoxycarbonyl-amino)-phenyl-N-butyl-2-methyl-carbanilat 
• 67103-31-5 C₂₂H₂₄N₂O₄ 
• 55240-17-0 C₁₂H₁₆ClNO 
• 861560-10-3 N-butyl-N-nitroso-o-toluidide 

Relevant articles and documents

Aryl-Diadamantyl Phosphine Ligands in Palladium-Catalyzed Cross-Coupling Reactions: Synthesis, Structural Analysis, and Application

Synthesis, temperature-dependent NMR structure investigation and utilization of a new, stable and easily accessible aryl-diadamantylphosphine ligand family is reported. The bulky and electron-rich phosphorus center of the ligand enhances the catalytic activity of palladium in cross-coupling reactions of sterically demanding ortho-substituted aryl halides. In our study, we demonstrated the synthetic applicability of the new phosphine ligands in Buchwald-Hartwig and tosyl hydrazone coupling reactions.

PREPARATION OF SECONDARY AMINES WITH ELECTROPHILIC N-LINCHPIN REAGENTS

In one aspect, the present disclosure provides methods of preparing a secondary amine. In some embodiments, the secondary amine comprises two different groups or two identifical groups. Also provided herein are compositions for use in the preparation of the secondary amine.

Practical Singly and Doubly Electrophilic Aminating Agents: A New, More Sustainable Platform for Carbon-Nitrogen Bond Formation

Given the importance of amines in a large number of biologically active natural products, active pharmaceutical ingredients, agrochemicals, and functional materials, the development of efficient C-N bond-forming methods with wide substrate scope continues to be at the frontier of research in synthetic organic chemistry. Here, we present a general and fundamentally new synthetic approach for the direct, transition-metal-free preparation of symmetrical and unsymmetrical diaryl-, arylalkyl-, and dialkylamines that relies on the facile single or double addition of readily available C-nucleophiles to the nitrogen atom of bench-stable electrophilic aminating agents. Practical single and double polarity reversal (i.e., umpolung) of the nitrogen atom is achieved using sterically and electronically tunable ketomalonate-derived imines and oximes. Overall, this novel approach represents an operationally simple, scalable, and environmentally friendly alternative to transition-metal-catalyzed C-N cross-coupling methods that are currently used to access structurally diverse secondary amines.