72781-99-8 Usage
General Description
1-(2-chloroethyl)-1-nitroso-3-[2-(1-oxidopyridin-2-yl)ethyl]urea is a chemical compound with the molecular formula C9H12ClN5O3. It is a nitrosourea derivative, which is a type of alkylating agent. 1-(2-chloroethyl)-1-nitroso-3-[2-(1-oxidopyridin-2-yl)ethyl]urea has potential antitumor activity, and it is being studied for its use in cancer therapy. It works by interfering with the DNA in cancer cells, preventing them from multiplying and ultimately leading to cell death. This chemical is still in the research and development stage, and its full potential in cancer treatment is still being evaluated.
Check Digit Verification of cas no
The CAS Registry Mumber 72781-99-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,2,7,8 and 1 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 72781-99:
(7*7)+(6*2)+(5*7)+(4*8)+(3*1)+(2*9)+(1*9)=158
158 % 10 = 8
So 72781-99-8 is a valid CAS Registry Number.
72781-99-8Relevant articles and documents
Nitrosation of 1-Substituted 3-(2-Pyridylmethyl)ureas and Related Compounds
Kamiya, Shozo,Sueyoshi, Shoko
, p. 1738 - 1742 (2007/10/02)
Nitrosation of 1-methyl- (Ia), 1-(2-chloroethyl)- (Ib) and 1-phenyl-3-(2-pyridylmethyl)urea (Id) with hydrochloric acid and sodium nitrite gave exclusively the corresponding 1-nitrosoureas (IIa,b,d).However, nitrosation of the 1-isopropylurea (Ic) gave a mixture of the 1-nitrosourea (IIc) and the 3-nitrosourea (IIIc).Similar results were also obtained in the nitrosation of 1-substituted 3-(2-pyridyl)ureas (Ie-h).The reaction of the nitrosoureas and m-chloroperbenzoic acid in chloroform gave the N-oxides (IVa-f, Vc,f,g), which were more stable than the nitrosoureas.Keywords-nitrosourea; 1-substituted 3-(2-pyridylmethyl)nitrosourea; 1-substituted 3-(2-pyridylethyl)nitrosourea; nitrosation; antitumor activity
