727993-33-1 Usage
Description
6-Methoxy-2-trifluoromethyl-3-nitropyridine is a chemical compound characterized by the presence of a methoxy group at the 6th position, a trifluoromethyl group at the 2nd position, and a nitro group at the 3rd position on a pyridine ring. 6-Methoxy-2-trifluoromethyl-3-nitropyridine serves as an important intermediate in the synthesis of various pharmaceuticals and agrochemicals due to its unique structural features and reactivity.
Uses
Used in Pharmaceutical Industry:
6-Methoxy-2-trifluoromethyl-3-nitropyridine is used as a key intermediate in the synthesis of pyrazinones, which are known as corticotropin-releasing factor-1 (CRF1) receptor antagonists. These antagonists play a crucial role in the treatment of stress-related disorders, such as anxiety, depression, and post-traumatic stress disorder (PTSD), by modulating the activity of the hypothalamic-pituitary-adrenal (HPA) axis.
In the synthesis process, 6-Methoxy-2-trifluoromethyl-3-nitropyridine undergoes a series of chemical reactions, including nucleophilic substitution, reduction, and cyclization, to form the desired pyrazinone derivatives. The presence of the methoxy, trifluoromethyl, and nitro groups in the molecule contributes to the overall biological activity and selectivity of the resulting CRF1 receptor antagonists.
Furthermore, the unique structural features of 6-Methoxy-2-trifluoromethyl-3-nitropyridine, such as the electron-withdrawing trifluoromethyl group and the electron-donating methoxy group, can be exploited to fine-tune the physicochemical properties and pharmacokinetic profile of the synthesized pyrazinone derivatives. This allows for the development of more potent and selective CRF1 receptor antagonists with improved safety and efficacy profiles.
Check Digit Verification of cas no
The CAS Registry Mumber 727993-33-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,2,7,9,9 and 3 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 727993-33:
(8*7)+(7*2)+(6*7)+(5*9)+(4*9)+(3*3)+(2*3)+(1*3)=211
211 % 10 = 1
So 727993-33-1 is a valid CAS Registry Number.
InChI:InChI=1/C7H5F3N2O3/c1-15-5-3-2-4(12(13)14)6(11-5)7(8,9)10/h2-3H,1H3
727993-33-1Relevant articles and documents
Therapeutically Active Thiazolo-Pyrimidine Derivatives
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Paragraph 0290, (2014/10/29)
A series of thiazolo[5,4-d]pyrimidine derivatives of formula (I) or an N-oxide thereof, or a pharmaceutically acceptable salt or solvate thereof: (I) Q represents a group of formula (Qa), (Qb), (Qc), (Qd) or (Qe) are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases; and organ and cell transplant rejection.
Heterocyclic cyclopropyl-substituted FXR binding compounds
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Page/Page column 20-21, (2009/12/23)
The present invention relates to compounds defined by formula (I): or an enantiomer, diastereomer, tautomer, solvate or pharmaceutically acceptable salt thereof, wherein R1 and R2 are independently from each other selected from hydro
COMPOUNDS AS CRF1 RECEPTOR ANTAGONISTS
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Page 27, (2010/02/09)
The present invention relates to compounds of Formula I,or a stereoisomer thereof, a pharmaceutically acceptable salt thereof, or a prodrug thereof. The compounds of the inventions are CRF, receptor antagonists. Compounds of the invention are useful for t
