72873-74-6 Usage
Description
6-(4-FLUOROPHENYL)-2,3-DIHYDRO-5-(4-PYRIDINYL)IMIDAZO[2,1-B]THIAZOLE DIHYDROCHLORIDE, also known as SKF 86002, is an anti-inflammatory agent with potent inhibitory effects on various inflammatory mediators and enzymes. It exhibits inhibitory activity against rat seminal vesicle prostaglandin H2 (PGH2) synthase, prostanoid production by rat basophilic leukemia (RBL-1) cells and human monocytes, leukotriene B4 (LTB4) and LTC4 production in human neutrophils and monocytes, and LPS-induced IL-1 production in human monocytes. Additionally, SKF 86002 demonstrates anti-inflammatory effects in rat models of adjuvantor collagen-induced arthritis and improves survival in a mouse model of LPS and galactosamine-induced endotoxic shock.
Uses
Used in Pharmaceutical Industry:
6-(4-FLUOROPHENYL)-2,3-DIHYDRO-5-(4-PYRIDINYL)IMIDAZO[2,1-B]THIAZOLE DIHYDROCHLORIDE is used as an anti-inflammatory agent for its ability to inhibit the production of various inflammatory mediators and enzymes, such as prostaglandin H2 (PGH2) synthase, prostanoids, leukotrienes, and IL-1.
Used in Research Applications:
6-(4-FLUOROPHENYL)-2,3-DIHYDRO-5-(4-PYRIDINYL)IMIDAZO[2,1-B]THIAZOLE DIHYDROCHLORIDE is used as a research tool for studying the role of inflammatory mediators and enzymes in various disease models, including arthritis and endotoxic shock.
Used in Drug Development:
6-(4-FLUOROPHENYL)-2,3-DIHYDRO-5-(4-PYRIDINYL)IMIDAZO[2,1-B]THIAZOLE DIHYDROCHLORIDE is used as a lead compound in the development of new anti-inflammatory drugs targeting p53, Cox, and 5-LO pathways.
Biological Activity
Inhibitor of p38 MAP kinase (IC 50 = 0.1-1 μ M). Potently inhibits LPS-induced IL-1 and TNF- α production in human monocytes (IC 50 = 1 μ M). Also inhibits 5-lipoxygenase- and cyclooxygenase-mediated arachidonic acid metabolism in RBL-1 cells (IC 50 values are 10 and 100 μ M respectively). Anti-inflammatory following oral administration in vivo .
Check Digit Verification of cas no
The CAS Registry Mumber 72873-74-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,2,8,7 and 3 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 72873-74:
(7*7)+(6*2)+(5*8)+(4*7)+(3*3)+(2*7)+(1*4)=156
156 % 10 = 6
So 72873-74-6 is a valid CAS Registry Number.
InChI:InChI=1/C16H12FN3S.2ClH/c17-13-3-1-11(2-4-13)14-15(12-5-7-18-8-6-12)20-9-10-21-16(20)19-14;;/h1-8H,9-10H2;2*1H
72873-74-6Relevant articles and documents
Synthetic and Mechanistic Studies on the Preparation of Pyridyl-Substituted Imidazothiazoles
Lantos, Ivan,Gombatz, Kerry,McGuire, Michael,Pridgen, Lendon,Remich, James,Shilcrat, Susan
, p. 4223 - 4227 (2007/10/02)
A new method is presented for the introduction of the 4'-pyridyl substituent into 6-aryl-2,3-dihydroimidazothiazoles.The method involves treatment of the imidazothiazolines with the reactive complex of pyridine and ethyl chloroformate and oxidative deethyl carboxylation of the dihydropyridine adducts formed.Sulfur in refluxing mesitylene was found most suitable for the latter reaction, but chromium trioxide in pyridine or KtBuO and air were also effective.
