72988-03-5

Basic information

• Product Name: N-{4-[({2-amino-5-[(2-chloroethyl)carbamoyl]-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl}methyl)amino]benzoyl}glutamic acid
• Synonyms: glutamic acid, N-[4-[[[2-amino-5-[[(2-chloroethyl)amino]carbonyl]-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl]methyl]amino]benzoyl]-; N-{4-[({2-amino-5-[(2-chloroethyl)carbamoyl]-4-hydroxy-5,6,7,8-tetrahydropteridin-6-yl}methyl)amino]benzoyl}glutamic acid
• CAS NO: 72988-03-5
• Molecular Formula: C₂₂H₂₇ClN₈O₇
• Molecular Weight: 550.9522
• Mol File: 72988-03-5.mol
• Article Data: 1

Chemical Properties

• Density: 1.68g/cm³
• Refractive Index: 1.734
• CAS DataBase Reference: N-{4-[({2-amino-5-[(2-chloroethyl)carbamoyl]-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl}methyl)amino]benzoyl}glutamic acid(CAS DataBase Reference)
• NIST Chemistry Reference: N-{4-[({2-amino-5-[(2-chloroethyl)carbamoyl]-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl}methyl)amino]benzoyl}glutamic acid(72988-03-5)
• EPA Substance Registry System: N-{4-[({2-amino-5-[(2-chloroethyl)carbamoyl]-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl}methyl)amino]benzoyl}glutamic acid(72988-03-5)

Safety Data

• Hazardous Substances Data: 72988-03-5(Hazardous Substances Data)

Upstream product

• 135-16-0 tetrahydrofolic acid 
• 1943-83-5 2-chloroethyl isothiocyanate 

Relevant articles and documents

Potential anticancer agents: 5-(N-substituted-aminocarbonyl)- and 5-(N-substituted-aminothiocarbonyl)-5,6,7,8-tetrahydrofolic acids

5-[[N-[(Ethoxycarbonyl)alkyl]amino]carbonyl] (6-9) and the corresponding aminothiocarbonyl (12-15) derivatives of 5,6,7,8-tetrahydrofolic acid were prepared as multisubstrate analogues of the substrate-cofactor adduct in the reactions catalyzed by the folate-mediated one-carbon transfer reactions. Evaluation in vitro showed that 7 (alkyl = hexyl) was cytotoxic to H.Ep-2 cells (ED50, 4 μM) but noncytotoxic to proliferating L1210 cells. No activity was observed for 7 against the P388 leukemia in mice.