7305-08-0

Basic information

• Product Name: 4-methylphenyl dimethylcarbamate
• Synonyms: Carbamic acid, dimethyl-, p-tolyl ester
• CAS NO: 7305-08-0
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.2157
• Mol File: 7305-08-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 257.9°C at 760 mmHg
• Flash Point: 109.8°C
• Density: 1.072g/cm³
• Vapor Pressure: 0.0141mmHg at 25°C
• Refractive Index: 1.519
• CAS DataBase Reference: 4-methylphenyl dimethylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methylphenyl dimethylcarbamate(7305-08-0)
• EPA Substance Registry System: 4-methylphenyl dimethylcarbamate(7305-08-0)

Safety Data

• Hazardous Substances Data: 7305-08-0(Hazardous Substances Data)

Upstream product

• 106-44-5 p-cresol 
• 68-12-2 N,N-dimethyl-formamide 
• 79-44-7 N,N-Dimethylcarbamoyl chloride 

Downstream Products

• 50670-50-3 p-(p-tolyl)benzonitrile 
• 1570134-48-3 N-(2-(4,5-dihydrooxazol-2-yl)phenyl)benzamide 
• 168265-56-3 1-benzyl-5-(4'-methyl-[1,1'-biphenyl]-2-yl)-1H-tetrazole 
• 452-86-8 4-methyl-1,2-dihydroxybenzene 
• 1631050-32-2 2-hydroxy-4-methylphenyl dimethylcarbamate 
• 1534364-37-8 2-bromo-4-methylphenyl dimethylcarbamate 
• 29285-53-8 2-chloro-4-methylphenyl-N,N-dimethylcarbamate 
• 1414838-13-3 (E)-ethyl 3-{2-[(N,N-dimethylcarbamoyl)oxy]-5-methylphenyl}acrylate 
• 1401518-60-2 1-(pyridin-2-yl)-2-(p-tolyl)-1H-indole 
• 1374451-54-3 2-(4,4'-dimethyl-[1,1'-biphenyl]-2-yl)pyridine 
• 380481-66-3 5,5-dimethyl-2-(4-methylphenyl)-1,3,2-dioxaborinane 

Relevant articles and documents

Copper porphyrin-catalyzed C(sp2)—O bond construction via coupling phenols with formamides

Copper porphyrin-catalyzed construction of C(sp2)—O bond via coupling formamides with phenols was achieved firstly. A broad range of substrates afforded various carbamates in moderate to good yields with good functional group tolerance at low catalyst loading. Intermolecular competing kinetic isotope effect experiment indicated that the generation of formamide radical is the rate-determining step of current cross-dehydrogenative coupling (CDC) reaction. The research extends the application of metalloporphyrin in CDC reaction.

Pd(II) catalyzed ortho C-H iodination of phenylcarbamates at room temperature using cyclic hypervalent iodine reagents

A novel approach to access ortho iodinated phenols using cyclic hypervalent iodine reagents through palladium(II) catalyzed C-H activation has been developed through weak coordination. The reaction showed excellent regioselectivity, reactivity and good functional group tolerance. A unique mechanism was proposed.

A general approach towards catechol and pyrogallol through ruthenium- and palladium-catalyzed C-H hydroxylation by weak coordination

An efficient ruthenium(II)- and palladium(II)-catalyzed C-H hydroxylation of aryl carbamates has been developed for the facile synthesis of catechols and pyrogallols. The reaction demonstrates excellent reactivity, regio- and chemoselectivity, good functional group compatibility and high yields. The practicality of this method has been proved by a gram-scale synthesis.