73083-00-8

Basic information

• Product Name: 2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-6,7-dimethoxy-1-(2-nitrophenyl)-, ethyl ester
• CAS NO: 73083-00-8
• Molecular Formula: C20H22N2O6
• Molecular Weight: 386.404
• Mol File: 73083-00-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-6,7-dimethoxy-1-(2-nitrophenyl)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-6,7-dimethoxy-1-(2-nitrophenyl)-, ethyl ester(73083-00-8)
• EPA Substance Registry System: 2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-6,7-dimethoxy-1-(2-nitrophenyl)-, ethyl ester(73083-00-8)

Safety Data

• Hazardous Substances Data: 73083-00-8(Hazardous Substances Data)

Upstream product

• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 17889-63-3 N-<2-(3,4-Dimethoxyphenyl)ethyl>carbamidsaeureethylester 
• 552-89-6 2-nitro-benzaldehyde 

Relevant articles and documents

One-pot α-amidosulfone-mediated variation of the pictet-Spengler tetrahydroisoquinoline synthesis, suitable for amide-type substrates

The development of Pictet-Spengler reactions from amide substrates is a challenging problem. We report here that the reaction between amide-type compounds (including carbamates, amides, ureas and diketopiperazines), aldehydes and p-toluenesulfinic acid constitutes an efficient method for the preparation of tetrahydroisoquinolines or pyrazino-[2,1-b]isoquinolines. Unlike previously known methods, this one-pot Pictet-Spengler protocol avoids the need for strong Lewis or Br?nsted acid catalysts.