73200-73-4

Basic information

• Product Name: 3-phenylpyrazin-2-ol
• Synonyms: 3-phenylpyrazin-2-ol;Pyrazinol, 3-phenyl-;cefaclor iMpurity F;3-Phenylpyrazinol
• CAS NO: 73200-73-4
• Molecular Formula: C10H8N2O
• Molecular Weight: 172.18332
• Mol File: 73200-73-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 457.4°Cat760mmHg
• Flash Point: 230.5°C
• Appearance: /
• Density: 1.2g/cm³
• Vapor Pressure: 5.48E-09mmHg at 25°C
• Refractive Index: 1.623
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• PKA: 7.87±0.30(Predicted)
• CAS DataBase Reference: 3-phenylpyrazin-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-phenylpyrazin-2-ol(73200-73-4)
• EPA Substance Registry System: 3-phenylpyrazin-2-ol(73200-73-4)

Safety Data

• Hazardous Substances Data: 73200-73-4(Hazardous Substances Data)

Usage

Description

3-Phenylpyrazin-2-ol is an organic compound that features a pyrazine ring with a hydroxyl group at the 2nd position and a phenyl group at the 3rd position. It is known for its potential applications in various fields due to its unique chemical structure and properties.

Uses

Used in Pharmaceutical Industry:
3-Phenylpyrazin-2-ol is used as a key intermediate in the synthesis of pharmaceutical compounds. Its presence in the structure of 2-Hydroxypyrazine, which is utilized in the development of potential antioxidants, makes it valuable for creating new drugs with antioxidant properties.
Used in Chemical Synthesis:
3-Phenylpyrazin-2-ol is used as a building block in the preparation of various chemical compounds, particularly in the synthesis of 2-substituted pyrazine derivatives. These derivatives have potential applications in different industries, including the development of antibacterial agents.

InChI:InChI=1/C10H8N2O/c13-10-9(11-6-7-12-10)8-4-2-1-3-5-8/h1-7H,(H,12,13)

Upstream product

• 64753-81-7 cefaclor 
• 98-80-6 phenylboronic acid 
• 62-53-3 aniline 

Downstream Products

• 243472-81-3 2-phenyl-3-trimethylsilanyloxy-pyrazine 
• 17705-33-8 3-phenylpyrazine-2-thiol 

Relevant articles and documents

Isolation and structure elucidation of a novel product of the acidic degradation of cefaclor

The acidic aqueous degradation of cefaclor, an orally administered cephalosporin antibiotic, has been investigated. The most prominent peak in the high-performance liquid chromatography profile of a degraded solution of cefaclor was isolated by preparative high-performance liquid chromatography. Mechanistically, the formation of this degradent from cefaclor involves a condensation of two cefaclor degradation products in which both products have undergone contraction from a six-membered cephem ring to a five-membered thiazole ring, presumably via a common episulfonium ion intermediate.

Electrochemical Cross-Coupling of C(sp2)?H with Aryldiazonium Salts via a Paired Electrolysis: an Alternative to Visible Light Photoredox-Based Approach

Photoredox-based C?H bond functionalization constitutes one of the most powerful and atom-economical approaches to organic syntheses. During this type of reaction, single electron transfer takes place between the photocatalyst (PC) and redox- active substrates. Electrosynthesis also involves electron transfer between substrates and electrodes. In this paper, we focus upon electrochemical cross-coupling of C(sp2)?H with aryldiazonium salts and have developed an efficient electrochemical approach to the Minisci-type arylation reaction. The constant current paired electrosynthesis proceeds in a simple undivided cell without external supporting electrolyte, features a wide range of substrates and is easy to scale-up. These results demonstrate that photoredox-based cross-coupling of C(sp2)?H with aryldiazonium salts can also proceed successfully under paired electrolysis conditions, thereby contributing to understanding of the parallels between photosynthesis and electrosynthesis. (Figure presented.).