73220-33-4

Basic information

• Product Name: 2-Propen-1-one, 3-(dimethylamino)-1-(2-hydroxy-4-methoxyphenyl)-
• Synonyms: trans-3-(dimethylamino)-1-(2-hydroxy-4-methoxyphenyl)prop-2-en-1-one;(E)-3-dimethylamino-1-(2-hydroxy-4-methoxyphenyl)propenone;2-Propen-1-one,3-(dimethylamino)-1-(2-hydroxy-4-methoxyphenyl);(2E)-3-(dimethylamino)-1-(2-hydroxy-4-methoxyphenyl)-2-propen-1-one;3-Dimethylamino-1-(2-hydroxy-4-methoxyphenyl)-2-propen-1-on;3-dimethylamino-1-(2-hydroxy-4-methoxyphenyl)propenone
• CAS NO: 73220-33-4
• Molecular Formula: C12H15NO3
• Molecular Weight: 221.256
• Mol File: 73220-33-4.mol
• Article Data: 37

Chemical Properties

• CAS DataBase Reference: 2-Propen-1-one, 3-(dimethylamino)-1-(2-hydroxy-4-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propen-1-one, 3-(dimethylamino)-1-(2-hydroxy-4-methoxyphenyl)-(73220-33-4)
• EPA Substance Registry System: 2-Propen-1-one, 3-(dimethylamino)-1-(2-hydroxy-4-methoxyphenyl)-(73220-33-4)

Safety Data

• Hazardous Substances Data: 73220-33-4(Hazardous Substances Data)

Upstream product

• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 
• 68-12-2 N,N-dimethyl-formamide 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 1188-33-6 N,N-dimethylformamide diethyl diacetal 
• 100-06-1 1-(4-methoxyphenyl)ethanone 

Downstream Products

• 1609205-22-2 methyl 4-(cyclohexylamino)-7-methoxy-1,3,10-trioxo-2-phenyl-1,2,3,10-tetrahydrochromeno[2,3-f]isoindole-11-carboxylate 
• 1609205-32-4 methyl 4-(cyclohexylamino)-7-methoxy-2-methyl-1,3,10-trioxo-1,2,3,10-tetrahydrochromeno[2,3-f]isoindole-11-carboxylate 
• 1609205-36-8 methyl 4-(cyclohexylamino)-7-methoxy-1,3,10-trioxo-3,10-dihydro-1H-furo[3,4-b]xanthene-11-carboxylate 
• 1609205-39-1 methyl 4-(benzylamino)-7-methoxy-1,3,10-trioxo-1,2,3,10-tetrahydrochromeno[2,3-f]isoindole-11-carboxylate 

Relevant articles and documents

Synthesis of novel isoflavone/benzo-δ-sultam hybrids as potential anti-inflammatory drugs

A small series of novel isoflavone/benzo-δ-sultam hybrids was synthesised and evaluated as potential anti-inflammatory and neuroprotective drugs in LPS-activated BV2 microglia. The benzo-δ-sultam core was constructed in a two-step reaction by coupling 2-halobenzenesulfonamide derivatives with terminal alkynes, followed by a 6-endo-dig cyclisation. The synthesised compounds, including precursors and hybrids, were tested for their ability to inhibit NO and TNF-α production in LPS-stimulated BV2 microglial cells, and the results are promising. The most potent hybrid reduces the NO production to 41%, and the TNF-α to 34% at 20 μM final concentration in the well.

Preparation method and device of 7-methoxy-4'-methyl formate flavanone

The invention relates to the technical field of preparation of flavonoid compounds, in particular to a preparation method of 7-methoxy-4'-methyl formate flavanone and a device thereof. The preparation method comprises the following steps: preparing 3-dimethylamino-1-(2'-hydroxyl-4'-methoxyphenyl)-2-ene-1-one, preparing 7-methoxy-4H-chromene-4-ketone; and preparing 7-methoxy-4'-methyl formate flavanone. The preparation device matched with the preparation method is provided, the preparation device comprises a box body, a control panel, a heating kettle and a support, the heating kettle is arranged on the inner side of the box body, unnecessary operation in the preparation process is effectively reduced through an overflow pipe and a clamp, a new synthesis path is provided, therefore, reagents used for synthesis are effectively reduced, reaction conditions are effectively reduced, and good reproducibility is achieved.

TBN-triggered, manipulable annulations of: O -hydroxyarylenaminones for divergent syntheses of oximinochromanones and oximinocoumaranones

Divergent synthesis provides an indispensable route to rapid acquisition of structurally diverse chemical scaffolds from identical starting materials. Herein, we describe unprecedented divergent annulations of o-hydroxyarylenaminones promoted by tert-butyl nitrite (TBN) under mild conditions. Two different types of benzo-oxa-heterocycle, including oximinochromanones and oximinocoumaranones, were smoothly assembled with a broad substrate scope and good functional group compatibility.