73333-79-6Relevant articles and documents
Efficient synthesis of tertiary acyclic amides by the Chapman rearrangement of aryl benzimidates in ionic liquids
Epishina, Margarita A.,Kulikov, Alexander S.,Ignat'Ev, Nikolai V.,Schulte, Michael,Makhova, Nina N.
, p. 126 - 128 (2015/04/14)
The Chapman rearrangement of aryl N-arylbenzimidates to tertiary acyclic amides is accelerated in ionic liquids and proceeds at lower temperatures as 120-190°C.
A general and efficient CuBr2-catalyzed N-arylation of secondary acyclic amides
Wang, Mangang,Yu, Hua,You, Xinwen,Wu, Jun,Shang, Zhicai
, p. 2356 - 2362,7 (2020/09/16)
A general and efficient Cu(II)-catalyzed cross-coupling method is reported for the preparation of acyclic tertiary amides. Generally moderate to excellent yields and functional group tolerance were obtained with secondary acyclic amides and aryl halides as substrates in toluene. A general and efficient Cu(II)-catalyzed cross-coupling method is reported for the preparation of acyclic tertiary amides. Generally moderate to excellent yields and functional group tolerance were obtained with secondary acyclic amides and aryl halides as substrates in toluene. Copyright
The use of lithium amides in the palladium-mediated synthesis of [carbonyl-11C]amides
Itsenko, Oleksiy,Blom, Elisabeth,Langstroem, Bengt,Kihlberg, Tor
, p. 4337 - 4342 (2008/04/13)
Weakly nucleophilic amines were converted into the corresponding lithium amides and used in either one- or two-pot palladium-mediated reactions with [11C]carbon monoxide and aryl iodides. It was found that palladium acyl complexes may be prepared in a separate step and have sufficient life-time to be used in a subsequent reaction with a nucleophile. This two-pot procedure was used for the labelling synthesis of eleven amides (nine of which are analogues of WAY-100635, a 5-HT1A radioligand) from weakly nucleophilic amines. The results were compared to a direct one-pot procedure using lithium amides. Both approaches extend the scope of palladium-mediated carbonylation using [11C]carbon monoxide and aryl iodides allowing use of weakly nucleophilic amines. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.