73397-12-3

Basic information

• Product Name: 6-CHLORO-9-NITRO-5-OXO-5H-BENZO[A]PHENOXAZINE
• Synonyms: CNOB;6-CHLORO-9-NITRO-5-OXO-5H-BENZO[A]PHENOXAZINE;6-Chloro-9-nitro-5H-benzo[a]phenoxazin-5-one
• CAS NO: 73397-12-3
• Molecular Formula: C16H7ClN2O4
• Molecular Weight: 326.69
• Mol File: 73397-12-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 445.3 °C at 760 mmHg
• Flash Point: 223.1 °C
• Appearance: /
• Density: 1.63 g/cm³
• Vapor Pressure: 4.01E-08mmHg at 25°C
• Refractive Index: 1.755
• CAS DataBase Reference: 6-CHLORO-9-NITRO-5-OXO-5H-BENZO[A]PHENOXAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-CHLORO-9-NITRO-5-OXO-5H-BENZO[A]PHENOXAZINE(73397-12-3)
• EPA Substance Registry System: 6-CHLORO-9-NITRO-5-OXO-5H-BENZO[A]PHENOXAZINE(73397-12-3)

Safety Data

• Hazardous Substances Data: 73397-12-3(Hazardous Substances Data)

Usage

Uses

6-Chloro-9-nitro-5-oxo-5H-benzo[a]phenoxazine or CNOB is a new prodrug enzyme cancer chemotherapy.

InChI:InChI=1/C16H7ClN2O4/c17-13-15(20)10-4-2-1-3-9(10)14-16(13)23-12-7-8(19(21)22)5-6-11(12)18-14/h1-7H

Upstream product

• 117-80-6 2,3-Dichloro-1,4-naphthoquinone 
• 121-88-0 5-Nitro-2-aminophenol 
• 603-85-0 2-Amino-3-nitrophenol 

Relevant articles and documents

Novel phenoxazinone derivatives as enzyme substrates and use thereof as indicator in the detection of microorganisms with peptidase activity

The present invention relates to novel enzymatic substrates with the following general formula: where R1, R2, R3, R4, R5, R6, A and X are as defined in claim 1, the reaction media comprising the same and the use thereof for the detection and/or identification and/or quantification of microorganisms expressing at least one peptidase activity.

Quinone Chemistry. Reaction of 2,3-Dichloro-1,4-naphthoquinone with o-Aminophenols under Various Conditions

The reaction of 2,3-dichloro-1,4-naphthochinone (1) and o-aminophenols (2) under various reaction conditions was reinvestigated.Despite earlier literature, 1 and 2a in alcohol react to give a mixture of 6-chloro-12a-hydroxy-5H-benzophenoxazin-5-one (4a), 6-chloro-12a-alkoxy-5H-benzophenoxazin-5-one (5), 6-chloro-5H-benzophenoxazin-5-one (7a), 2-amino-3H-phenoxazin-3-one (8) and triphenodioxazine (9a).Contradictory to earlier findings, 1 and 2a in MeOH/KOH afford 7a but the highest yield of the compound is achieved by using EtOH or MeOH and anhydrous potassium acetate.A probable mechanism for the formation of all reaction products is presented and detailed spectroscopic data of all compounds are given.