73458-39-6

Basic information

• Product Name: 5-NITRO-BENZOTHIAZOL-2-YLAMINE
• Synonyms: SALOR-INT L133531-1EA;2-AMINO-5-NITROBENZOTHIAZOLE;5-NITRO-BENZOTHIAZOL-2-YLAMINE;2-Benzothiazolamine,5-nitro-(9CI);5-Nitro-1,3-benzothiazol-2-amine;2-AMINO-5-NITROBENZOTHIZOLE;2-BenzothiazolaMine,5-nitro-;5-Nitrobenzo[d]thiazol-2-aMine
• CAS NO: 73458-39-6
• Molecular Formula: C₇H₅N₃O₂S
• Molecular Weight: 195.2
• Product Categories: BENZOTHIAZOLE
• Mol File: 73458-39-6.mol
• Article Data: 22

Chemical Properties

• Melting Point: 308-309 °C (decomp)
• Boiling Point: 411.7°C at 760 mmHg
• Flash Point: 202.8°C
• Appearance: /
• Density: 1.621g/cm³
• Vapor Pressure: 5.48E-07mmHg at 25°C
• Refractive Index: 1.797
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 2.22±0.10(Predicted)
• CAS DataBase Reference: 5-NITRO-BENZOTHIAZOL-2-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-NITRO-BENZOTHIAZOL-2-YLAMINE(73458-39-6)
• EPA Substance Registry System: 5-NITRO-BENZOTHIAZOL-2-YLAMINE(73458-39-6)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 73458-39-6(Hazardous Substances Data)

Usage

General Description

5-NITRO-BENZOTHIAZOL-2-YLAMINE is a chemical compound with the molecular formula C7H5N3O2S. It is a yellow solid with a melting point of 215-219 degrees Celsius and is insoluble in water. 5-NITRO-BENZOTHIAZOL-2-YLAMINE is commonly used as a reagent in organic synthesis and pharmaceutical research. It is known for its potential as an antimicrobial and antiparasitic agent, and has been investigated for its potential use in the treatment of various diseases. Additionally, 5-NITRO-BENZOTHIAZOL-2-YLAMINE has been studied for its potential use as an anticancer agent, as well as for its antifungal and antioxidant properties. However, it is important to note that this compound should be handled with care due to its potential toxicity.

InChI:InChI=1/C7H5N3O2S/c8-7-9-5-3-4(10(11)12)1-2-6(5)13-7/h1-3H,(H2,8,9)

Upstream product

• 2942-07-6 5-nitrobenzothiazole 
• 1594-56-5 2,4-dinitro-phenyl thiocyanate 
• 333741-82-5 1-benzoyl-3-(2-fluoro-5-nitrophenyl)thiourea 
• 99-09-2 3-nitro-aniline 
• 3425-46-5 potassium selenocyanate 
• 333-20-0 potassium thioacyanate 
• 1147550-11-5 ammonium thiocyanate 
• 17356-08-0 thiourea 
• 97-00-7 1-chloro-2,4-dinitro-benzene 
• 84387-89-3 3-amino-5-nitro-1,2-benzisothiazole 
• 2217-55-2 bis(2,4-dinitrophenyl) disulphide 
• 341036-37-1 N-((2-chloro-5-nitrophenyl)carbamothioyl)benzamide 
• 6283-25-6 H₂NC₆H₃(Cl)NO₂ 
• 369-36-8 6-fluoro-3-nitroaniline 

Downstream Products

• 80945-80-8 (5-nitro-benzothiazol-2-yl)-hydrazine 
• 50480-29-0 benzo[d]thiazole-2,5-diamine 
• 1223564-48-4 1-benzoyl-3-(5-nitrobenzo[d]thiazol-2-yl) thiourea 
• 1223564-40-6 1-(5-nitrobenzo[d]thiazol-2-yl)-3-(4-nitrobenzoyl) thiourea 
• 1240167-86-5 2,3-bis(4-methoxyphenyl)-6-nitroimidazo[2,1-b][1,3]benzothiazole 
• 1240167-94-5 C₂₃H₁₇N₃O₃S 
• 1448530-56-0 (E)-3-(5-nitrobenzo[d]thiazol-2-yl)-2-styryl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one 
• 1448530-43-5 3-(5-nitrobenzo[d]thiazol-2-yl)-2-(3,4,5-trimethoxyphenyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one 
• 1315085-60-9 C₂₁H₁₆N₁₀O₅S₃ 
• 3507-44-6 2-bromo-5-nitrobenzo[d]thiazole 
• 1357251-54-7 N-(5-nitrobenzo[d]thiazol-2-yl)-2-(4-phenylpiperazin-1-yl)acetamide 
• 100856-56-2 2-benzoylamino-5-nitro-1,3-benzothiazole 
• 659743-51-8 1-(2-aminobenzothiazol-5-yl)-3-benzoylthiourea 
• 939795-82-1 C₁₉H₂₁N₄SF 

Relevant articles and documents

Photochemistry of 5-nitro-1,2-benzisothiazole derivatives: effects of substituents, solvents and excitation wavelength

3-R-5-Nitro-1,2-benzisothiazole derivatives (1, R = substituents) in solution, undergo photochemical isomerization to produce 2-R-5-nitro-1,2-benzothiazole derivatives. Here, generalizations and limitations by the substituent, solvent, and excitation wave

Synthesis and anticonvulsant evaluation of indoline derivatives of functionalized aryloxadiazole amine and benzothiazole acetamide

A series of N-(substituted benzothiazole-2-yl)-2-(2,3-dioxoindolin-1-yl)acetamide (4a-i) and substituted-[3-((5-phenyl-1,3,4-oxadiazole-2-yl)imino)indolene-2-one] (5a-f) were designed, synthesized fulfilling the structural requirement of pharmacophore and evaluated for anticonvulsant activities using maximal electroshock test (MES), subcutaneous pentylenetetrazole (scPTZ) seizures and neurotoxicity by motor impairment model in mice. The most active compoundN-(5-chlorobenzo[d]thiazol-2-yl)-2-(2,3-dioxoindolin-1-yl)acetamide (4a) has shown significant anticonvulsant activity against both MES and scPTZ screens and emerged as most effective anticonvulsant compound with median dose of 35.7 mg/kg (MES ED50), 88.15 mg/kg (scPTZ ED50) and toxic dose (TD50) was found to be > 500mg/kg. In silico studies including molecular docking study was carried to establish the molecular interaction of potent compound (4a) in both Na+ channel and GABAA receptors. The prediction of pharmacokinetic parameters and distance mapping of compounds were also performed to establish the drug likeness property.

ANTIBIOTIC COMPOUNDS, PHARMACEUTICAL FORMULATIONS THEREOF AND METHODS AND USES THEREFOR

The present invention relates to compounds of formula (I) wherein G1 to G8 are as defined herein. The compounds are PK inhibitors and as such represent a new approach to treating pathogenic infections, including multidrug resistant pathogens. Disclosed herein are the compounds of formula (I), pharmaceutical compositions comprising the compounds of formula (I) and their use in the treatment of antimicrobial infection. (Formula (1))