73495-10-0

Basic information

• Product Name: (R)-3-AMINO-3-(2-THIENYL)-PROPIONIC ACID
• Synonyms: L-BETA-HOMO(2-THIENYL)-GLYCINE;H-THG(2)-(C*CH2)OH;H-GLY(2-THIENYL)-(C*CH2)OH;H-BETA-ALA-(2-THIENYL)-OH;(R)-3-AMINO-3-THIOPHEN-2-YL-PROPIONIC ACID;(R)-3-AMINO-3-(2-THIENYL)-PROPIONIC ACID;H-b-Ala-(2-thienyl)-OH;Albb-006625
• CAS NO: 73495-10-0
• Molecular Formula: C₇H₉NO₂S
• Molecular Weight: 171.22
• Product Categories: B-Amino
• Mol File: 73495-10-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 327.6 °C at 760 mmHg
• Flash Point: 151.9 °C
• Appearance: /
• Density: 1.345 g/cm³
• Vapor Pressure: 8.12E-05mmHg at 25°C
• Refractive Index: 1.606
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 3.33±0.12(Predicted)
• CAS DataBase Reference: (R)-3-AMINO-3-(2-THIENYL)-PROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-AMINO-3-(2-THIENYL)-PROPIONIC ACID(73495-10-0)
• EPA Substance Registry System: (R)-3-AMINO-3-(2-THIENYL)-PROPIONIC ACID(73495-10-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 73495-10-0(Hazardous Substances Data)

Usage

General Description

(R)-3-AMINO-3-(2-THIENYL)-PROPIONIC ACID is a chemical compound with the molecular formula C6H7NO2S. It is an amino acid derivative that contains a thienyl group. (R)-3-AMINO-3-(2-THIENYL)-PROPIONIC ACID may have potential applications in the pharmaceutical industry, particularly in the development of new drugs and medications.

InChI:InChI=1/C7H9NO2S/c8-5(4-7(9)10)6-2-1-3-11-6/h1-3,5H,4,8H2,(H,9,10)/t5-/m1/s1

Upstream product

• 2021-58-1 rac-3-(2-thienyl)alanine 
• 18389-46-3 3-amino-3-(thiophen-2-yl)propanoic acid 
• 22951-96-8 L-3-(2-thienyl)alanine 

Downstream Products

• 78175-21-0 (R)-3-(2,4-Dinitro-phenylamino)-3-thiophen-2-yl-propionic acid 

Relevant articles and documents

Influence of the aromatic moiety in α- And β-arylalanines on their biotransformation with phenylalanine 2,3-aminomutase from: Pantoea agglomerans

In this study enantiomer selective isomerization of various racemic α- and β-arylalanines catalysed by phenylalanine 2,3-aminomutase from Pantoea agglomerans (PaPAM) was investigated. Both α- and β-arylalanines were accepted as substrates when the aryl moiety was relatively small, like phenyl, 2-, 3-, 4-fluorophenyl or thiophen-2-yl. While 2-substituted α-phenylalanines bearing bulky electron withdrawing substituents did not react, the corresponding substituted β-aryl analogues were converted rapidly. Conversion of 3- and 4-substituted α-arylalanines happened smoothly, while conversion of the corresponding β-arylalanines was poor or non-existent. In the range of pH 7-9 there was no significant influence on the conversion of racemic α- or β-(thiophen-2-yl)alanines, whereas increasing the concentration of ammonia (ammonium carbonate from 50 to 1000 mM) inhibited the isomerization progressively and decreased the amount of the by-product (i.e. (E)-3-(thiophen-2-yl)acrylic acid was detected). In all cases, the high ee values of the products indicated excellent enantiomer selectivity and stereospecificity of the isomerization except for (S)-2-nitro-α-phenylalanine (ee 92%) from the β-isomer. Substituent effects were rationalized by computational modelling revealing that one of the main factors controlling biocatalytic activity was the energy difference between the covalent regioisomeric enzyme-substrate complexes.

β-styryl- and β-aryl-β-alanine products of phenylalanine aminomutase catalysis

The substrate specificity of a Taxus-derived phenylalanine aminomutase (PAM) was investigated, and the enzyme was found to catalyze the conversion of variously substituted vinyl- and aryl-S-∞-alanines to corresponding β-amino acids. This study shows the b