735-28-4

Basic information

• Product Name: 2-AMINO, N-(2-TRIFLUOROMETHYL PHENYL )BENZAMIDE
• Synonyms: 2-AMINO, N-(2-TRIFLUOROMETHYL PHENYL )BENZAMIDE
• CAS NO: 735-28-4
• Molecular Formula: C₁₄H₁₁F₃N₂O
• Molecular Weight: 280.2451496
• Mol File: 735-28-4.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-AMINO, N-(2-TRIFLUOROMETHYL PHENYL )BENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO, N-(2-TRIFLUOROMETHYL PHENYL )BENZAMIDE(735-28-4)
• EPA Substance Registry System: 2-AMINO, N-(2-TRIFLUOROMETHYL PHENYL )BENZAMIDE(735-28-4)

Safety Data

• Hazardous Substances Data: 735-28-4(Hazardous Substances Data)

Usage

Class

Organic compounds

Molecular weight

294.25 g/mol

Physical state

Brown powder

Main use

Pharmaceutical research and drug synthesis

Potential applications

Development of new medications

Specific properties

Vary depending on context and purpose of use

Upstream product

• 118-48-9 isatoic anhydride 
• 88-17-5 2-(trifluoromethyl)benzenamine 
• 314053-91-3 2-nitro-N-(2-trifluoromethylphenyl)benzamide 
• 67-56-1 methanol 
• 552-16-9 ortho-nitrobenzoic acid 
• 610-14-0 2-nitrobenzyl chloride 

Downstream Products

• 133040-61-6 2-[2-(1H-Indol-3-yl)-ethyl]-3-(2-trifluoromethyl-phenyl)-3H-quinazolin-4-one 
• 340-49-8 3-[2-(trifluoromethyl)phenyl]-2-methylquinazolin-4(3H)-one 

Relevant articles and documents

Copper-catalyzed radical methylation/C-H amination/oxidation cascade for the synthesis of quinazolinones

A copper-catalyzed radical methylation/sp3 C-H amination/oxidation reaction for the facile synthesis of quinazolinone was developed. In this cascade reaction, dicumyl peroxide acts not only as a useful oxidant but also as an efficient methyl source. Notably, a methyl radical, generated from peroxide, was confirmed by electron paramagnetic resonance for the first time.

Stannous chloride in alcohol: A one-pot conversion of 2-Nitro-N- arylbenzamides to 2,3-Dihydro-1H-quinazoline-4-ones

A novel one-step synthesis of 2,3-dihydro-1H-quinazolin-4-ones from 2-nitrobenzamides is reported. These reactions are mediated by stannous chloride in 0.02 M methanolic or ethanolic HCl solution and proceed in good yields.