73502-03-1

Basic information

• Product Name: 5-METHOXY-2-METHYL-BENZOIC ACID METHYL ESTER
• Synonyms: 5-METHOXY-2-METHYL-BENZOIC ACID METHYL ESTER;Methyl 3-methoxy-6-methylbenzoate
• CAS NO: 73502-03-1
• Molecular Formula: C₁₀H₁₂O₃
• Molecular Weight: 180.21
• Mol File: 73502-03-1.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 254.318°C at 760 mmHg
• Flash Point: 100.309°C
• Appearance: /
• Density: 1.075g/cm³
• Vapor Pressure: 0.017mmHg at 25°C
• Refractive Index: 1.503
• CAS DataBase Reference: 5-METHOXY-2-METHYL-BENZOIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHOXY-2-METHYL-BENZOIC ACID METHYL ESTER(73502-03-1)
• EPA Substance Registry System: 5-METHOXY-2-METHYL-BENZOIC ACID METHYL ESTER(73502-03-1)

Safety Data

• Hazardous Substances Data: 73502-03-1(Hazardous Substances Data)

Usage

General Description

5-Methoxy-2-methyl-benzoic acid methyl ester is a chemical compound with the molecular formula C10H12O3. It is a methyl ester derivative of 5-methoxy-2-methylbenzoic acid, a compound commonly found in various natural and synthetic products. This chemical is often used in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is also known for its potential applications in research and analytical chemistry. 5-Methoxy-2-methyl-benzoic acid methyl ester may also have some biological activities and can serve as a starting material for the preparation of other important chemical intermediates.

InChI:InChI=1/C10H12O3/c1-7-4-5-8(12-2)6-9(7)10(11)13-3/h4-6H,1-3H3

Upstream product

• 74-88-4 methyl iodide 
• 35450-36-3 methyl 2-bromo-5-methoxybenzoate 
• 544-97-8 dimethyl zinc(II) 
• 3168-59-0 5-methoxy-o-toluic acid 
• 578-22-3 2-methyl-5-hydroxybenzoic acid 
• 1975-52-6 5-nitro-o-toluic acid 
• 2840-04-2 5-amino-2-methylbenzoic acid 
• 77-78-1 dimethyl sulfate 
• 823-96-1 Trimethylboroxine 
• 857599-37-2 methyl 2-iodo-5-methoxybenzoate 
• 57772-57-3 5-hydroxy-2-iodo-benzoic acid 
• 394-31-0 2-amino-5-hydroxybenzoic acid 
• 67-56-1 methanol 
• 118-90-1 ortho-methylbenzoic acid 

Downstream Products

• 3168-59-0 5-methoxy-o-toluic acid 
• 96826-31-2 2-(5-methoxy-2-methyl-phenyl)-propan-2-ol 
• 73502-04-2 (5-methoxy-2-methylphenyl)methanol 
• 56724-09-5 5-methoxy-2-methylbenzaldehyde 
• 944718-10-9 2-Bromomethyl-6-methoxy-2,3-dihydro-isoindol-1-one 
• 944718-09-6 2,2-Dimethyl-propionic acid 6-methoxy-1-oxo-1,3-dihydro-isoindol-2-ylmethyl ester 
• 22246-66-8 6-methoxy-2,3-dihydro-isoindol-1-one 
• 659737-57-2 6-hydroxy-2,3-dihydro-1H-isoindol-1-one 
• 1265287-00-0 methyl 5-methoxy-2-(dibromomethyl)-benzoate 
• 788081-99-2 methyl 2-(bromomethyl)-5-methoxy-benzoate 

Relevant articles and documents

Palladium-Catalyzed Tandem Carbonylative Diels-Alder Reaction for Construction of Bridged Polycyclic Skeletons

A palladium-catalyzed tandem carbonylative lactonization and Diels-Alder cycloaddition reaction between aldehyde-tethered benzylhalides and alkenes has been developed. A range of alkenes and aldehyde-tethered benzylhalides bearing different substituents can be successfully transformed into the corresponding bridged polycyclic compounds in good yields. This strategy provides a unique approach to complex lactone-containing bridged polycyclic compounds.

Copper-promoted direct amidation of isoindolinone scaffolds by sodium persulfate

Isoindolinones are ubiquitous structural motifs in natural products and pharmaceuticals. Establishing an efficient method for structural modification of isoindolinones could significantly facilitate new drug development. Herein, we describe copper-promoted direct amidation of isoindolinone scaffolds mediated by sodium persulfate. The method exhibits mild reaction conditions and high site-selectivity, and enables the structural modification of the drug indobufen ester with various amides with yields of 49 to 98%. It is also gram-scalable. Additionally, the reaction mechanism appears to involve a radical and a carbocationic pathway.

FXR RECEPTOR MODULATOR, PREPARATION METHOD THEREFOR, AND USES THEREOF

The present disclosure disclosed a modulator of FXR receptor and preparation and use thereof, which relates to the technical filed of medicinal chemistry. The present disclosure provides a modulator of FXR receptor having a structural formula I or a pharmaceutically acceptable salt, stereoisomer, solvate or prodrug thereof, which can combine with FXR receptor (that is NR1H4) and be acted as a FXR agonist or a partial agonist for preventing and treating the disease mediated by FXR, such as chronic intrahepatic or extrahepatic cholestasis, hepatic fibrosis caused by chronic cholestasis or acute intrahepatic cholestasis, chronic hepatitis B, gallstone, hepatic carcinoma, colon cancer or intestinal inflammatory disease, etc. Specifically, for some chemical compounds, their EC50 for FXR agonist activity reach below 100nM, which show an excellent FXR agonist activity and an excellent prospect to provide a new pharmaceutical selection in clinical treatment for the disease mediated by FXR.