7351-49-7

Basic information

• Product Name: 5-AMINOMETHYL-DIBENZOSUBERANE
• Synonyms: 10,11-Dihydro-5H-dibenzo(A,D)cycloheptene-5-methylamine;5H-Dibenzo(A,D)cycloheptene-5-methylamine, 10,11-dihydro-;Brn 2807165;5H-Dibenzo[a,d]cycloheptene-5-MethanaMine, 10,11-dihydro-;(10,11-Dihydro-5H-dibenzo[a,d][7]annulen-5-yl)MethanaMine;(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-yl)methanamine(WXC04271)
• CAS NO: 7351-49-7
• Molecular Formula: C₁₆H₁₇N
• Molecular Weight: 223.31
• Mol File: 7351-49-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 348.3°C at 760 mmHg
• Flash Point: 165.2°C
• Appearance: /
• Density: 1.07g/cm³
• Vapor Pressure: 5.08E-05mmHg at 25°C
• Refractive Index: 1.598
• Storage Temp.: 2-8°C
• PKA: 9.61±0.29(Predicted)
• CAS DataBase Reference: 5-AMINOMETHYL-DIBENZOSUBERANE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMINOMETHYL-DIBENZOSUBERANE(7351-49-7)
• EPA Substance Registry System: 5-AMINOMETHYL-DIBENZOSUBERANE(7351-49-7)

Safety Data

• Hazardous Substances Data: 7351-49-7(Hazardous Substances Data)

Usage

General Description

5-Aminomethyl-dibenzosuberane is a chemical compound with the molecular formula C20H21N. It has a molecular weight of 275.39 grams per mole and a melting point of 175-177 degrees Celsius. 5-AMINOMETHYL-DIBENZOSUBERANE is used in organic synthesis and has potential applications in the pharmaceutical industry as a precursor to various drugs and pharmaceutical intermediates. It is a white to off-white crystalline solid that is insoluble in water but soluble in organic solvents such as ethanol and acetone. 5-aminomethyl-dibenzosuberane has a variety of potential uses and is an important building block in the synthesis of complex organic molecules.

InChI:InChI=1/C16H17N/c17-11-16-14-7-3-1-5-12(14)9-10-13-6-2-4-8-15(13)16/h1-8,16H,9-11,17H2

Upstream product

• 1210-33-9 5-chlorodibenzosuberane 
• 1729-63-1 10,11-dihydro-5H-dibenzo[a,d]cycloheptene-5-carbonitrile 

Relevant articles and documents

DIPEPTIDYL PEPTIDASE-IV INHIBITORS

The present invention relates generally to pyrrolidine and thiazolidine DPP-IV inhibitor compounds. The present invention also provides synthetic methods for preparation of such compounds, methods of inhibiting DPP-IV using such compounds and pharmaceutical formulations containing them for treatment of DPP-IV mediated diseases, in particular, Type-2 diabetes.

N-SUBSTITUTED DERIVATIVES OF 6,11-DIHYDRODIBENZOTHIEPIN-11-AMINE AND RELATED COMPOUNDS; SYNTHESIS AND PHARMACOLOGICAL SCREENING

Reactions of N-(6,11-dihydrodibenzothiepin-11-yl)chloroacetamide (II) with dimethylamine, morpholine, and 2-(1-piperazinyl)ethanol afforded the amino amides III-V.Substitution reactions of 11-chloro-6,11-dihydrodibenzothiepin with ethylenediamine and N,N-dimethylethylenediamine gave the diamines VI and VII. 6,11-Dihydrodibenzothiepin-11-amine (I) was treated with ethyl chloroacetate and ethyl 2-bromopropionate to give the amino esters X and XI which were transformed on the one hand to the acids VIII and IX, and to the amides XII and XIII on the other.(6,11-Dihydrodibenzothiepin-11-yl)methylamine (XVIa) and (10,11-dihydro-5H-dibenzocycloheptene-5-yl)methylamine (XVIb) were transformed via the chloroacetamides XVIIa and XVIIb to the (4-methyl-1-piperazinyl)acetamides XVa and XVb.Compound V showed local anaesthetic and antiarrhytmic activity, the diamine VII had antihistamine and antireserpine effects, the amide XII was found to be an anticonvulsant, and the piperazines XVa and XVb inhibited effectively the formation of the indomethacin-induced gastric ulcers in rats.