73550-55-7

Basic information

• Product Name: 1-AMINOCYCLOBUTANE-CIS-1,3-DICARBOXYLIC ACID
• Synonyms: CIS-ACBD;CIS-1-AMINOCYCLOBUTANE-1,3-DICARBOXYLIC ACID;CIS-2,4-METHANOGLUTAMIC ACID;1-AMINOCYCLOBUTANE-CIS-1,3-DICARBOXYLIC ACID;1-AMINOCYCLOBUTANE-TRANS-1,3-DICARBOXYLIC ACID;TRANS-ACBD;TRANS-1-AMINOCYCLOBUTANE-1,3-DICARBOXYLIC ACID;TRANS-2,4-METHANOGLUTAMIC ACID
• CAS NO: 73550-55-7
• Molecular Formula: C6H9NO4
• Molecular Weight: 159.14
• Product Categories: Glutamate receptor
• Mol File: 73550-55-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 288.1 °C at 760 mmHg
• Flash Point: 128 °C
• Appearance: /
• Density: 1.568 g/cm³
• Vapor Pressure: 0.000607mmHg at 25°C
• Refractive Index: 1.587
• Storage Temp.: Store at RT
• CAS DataBase Reference: 1-AMINOCYCLOBUTANE-CIS-1,3-DICARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1-AMINOCYCLOBUTANE-CIS-1,3-DICARBOXYLIC ACID(73550-55-7)
• EPA Substance Registry System: 1-AMINOCYCLOBUTANE-CIS-1,3-DICARBOXYLIC ACID(73550-55-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 73550-55-7(Hazardous Substances Data)

Usage

Uses

1-Aminocyclobutane-trans-1,3-dicarboxylic acid is a potent inhibitor of EAAT.

Biological Activity

Potent, competitive and selective inhibitor of glutamate uptake. Certain confusion exists over the naming of this compound because of apparent contradictions in the literature. This is the isomer which has the carboxylic acid and the amino groups on the same side of the cyclobutyl ring.

InChI:InChI=1/C6H9NO4/c7-6(5(10)11)1-3(2-6)4(8)9/h3H,1-2,7H2,(H,8,9)(H,10,11)/t3-,6+

Upstream product

• 23761-23-1 3-oxocyclobutanecarboxylic acid 
• 116129-01-2 N-(t-butoxycarbonyl)-1-carbomethoxy-2-azabicyclo[2.1.1]hexane 
• 127926-24-3 2-(tert-butoxycarbonyl)-2-azabicyclo[2.1.1]hexane-1-carboxylic acid 
• 73550-56-8 2-azabicyclo[2.1.1]hexane-1-carboxylic acid 
• 77422-38-9 methyl N-benzoyl-1-azabictclo<2.3.1>hexane-5-carboxylate 
• 77422-37-8 methyl N-allyl-2-benzamidopropenoate 
• 161181-47-1 cis-1-(benzoylamino)-1-(pentamethylenecarbamoyl)cyclobutane-3-carboxylate 
• 161181-44-8 3-(benzoylamino)-3-(pentamethylenecarbamoyl)-1-(phenylsulfonyl)cyclobutane-1-carboxylic acid 
• 158786-83-5 cis-1-amino-3-(phenylsulfonyl)cyclobutane-1-N,N-pentamethylenecarboxamide 
• 158786-87-9 cis-1-(benzoylamino)-3-(phenylsulfonyl)cyclobutane-1-N,N-pentamethylenecarboxamide 
• 158786-79-9 N,N-Pentamethylene-cis-3-(phenylsulfonyl)-1-triazenocyclobutane-1-carboxamide 
• 161181-43-7 1-Azido-3-benzenesulfonyl-cyclobutanecarbonyl chloride 
• 117488-02-5 cis-1-Azido-N,N-pentamethylene-3-(phenylsulfonyl)cyclobutane-1-carboxamide 
• 166667-00-1 dimethyl trans-1-benzoylamino-3-(phenylsulfonyl)cyclobutane-1,3-dicarboxylate 

Relevant articles and documents

SYNTHESIS OF AMINOCYCLOBUTANE MONO- AND DICARBOXYLIC ACIDS AND DERIVATIVES THEREOF FROM (PHENYLSULFONYL)BICYCLOBUTANES

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Synthesis and Activity of a Potent N-Methyl-D-aspartic Acid Agonist, trans-1-Aminocyclobutane-1,3-dicarboxylic Acid, and Related Phosphonic and Carboxylic Acids

We report the synthesis of a series of 3-carboxy-, 3-(carboxymethyl)-, 3-(1o-phosphoalkenyl)-, and 3-(1o-phosphonoalkyl)-1-aminocyclobutane-1-carboxylic acids for evaluation as agonists or antagonists of neurotransmission at excitatory amino acid receptor

Total Synthesis of Cyclobutane Amino Acids from Atelia herbert smithii

The syntheses of two amino acids from the seeds of the legume Atelia herbert smithii, 2,4-methanoproline and 2,4-methanoglutamic acid, are described.The synthesis of third amino acid, cis-1-amino-3-(hydroxymethyl)cyclobutanecarboxylic acid and subsequent