73583-39-8

Basic information

• Product Name: 3-Bromo-5-chloropyridine
• Synonyms: 3-BROMO-5-CHLOROPYRIDINE;5-bromo-3-chloropyridine;3-Bromo-5-chloropyri;3-broMo -5-chlorine pyridine;3--5-chlorine pyridinebroMide;3-BroMo-5-chloropyridine 97%;3-Bromo-5-chloropyridine,95%
• CAS NO: 73583-39-8
• Molecular Formula: C₅H₃BrClN
• Molecular Weight: 192.44
• EINECS: 1308068-626-2
• Product Categories: compounds of pyridine;blocks;Bromides;Pyridines;pharmacetical;Pyridine;C5Heterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Variety of halogenated heterocyclic series;Building Blocks;C5;C5 to C6;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;Heterocycle-Pyridine series;Oxetanes
• Mol File: 73583-39-8.mol
• Article Data: 1

Chemical Properties

• Melting Point: 80-82°C
• Boiling Point: 194.7 °C at 760 mmHg
• Flash Point: 71.5 °C
• Appearance: White to brown/Crystalline Powder
• Density: 1.736 g/cm³
• Vapor Pressure: 0.611mmHg at 25°C
• Refractive Index: 1.581
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: soluble in Methanol
• PKA: 0.59±0.20(Predicted)
• CAS DataBase Reference: 3-Bromo-5-chloropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-5-chloropyridine(73583-39-8)
• EPA Substance Registry System: 3-Bromo-5-chloropyridine(73583-39-8)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 20/21/22-36/37/38-41-37/38-22
• Safety Statements: 26-36/37/39
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• HazardClass: IRRITANT
• PackingGroup: III
• Hazardous Substances Data: 73583-39-8(Hazardous Substances Data)

Usage

General Description

3-Bromo-5-chloropyridine is an organic compound which belongs to the category of synthetic compounds known as halopyridines. It is composed of a pyridine ring, which is a heterocyclic aromatic six-member ring structure with a nitrogen atom replacing one carbon atom. 3-Bromo-5-chloropyridine is unique due to its functional groups, which include a bromine atom at the 3rd position and a chlorine atom at the 5th position on the pyridine ring. Primarily used in scientific research, 3-Bromo-5-chloropyridine is involved in various chemical reactions, especially in the fields of synthetic chemistry and pharmaceuticals. The CAS registry number for this compound is 67473-02-5. Care should be taken while handling, as it may be harmful if swallowed, inhaled, or come in contact with skin.

InChI:InChI=1/C5H3BrClN/c6-4-1-5(7)3-8-2-4/h1-3H

Upstream product

• 26163-03-1 2-amino-3-bromo-5-chloropyridine 
• 137628-17-2 2,3-dibromo-5-chloro-pyridine 

Downstream Products

• 1352420-43-9 C₂₄H₂₁ClF₂N₂O₃ 
• 887911-71-9 C₁₈H₁₇ClN₄O 
• 1070870-40-4 3-bromo-5-chloro-4-[3-(1-methylethyl)phenyl]pyridine 
• 1070870-59-5 methyl {4-{5-chloro-4-[3-(1-methylethyl)phenyl]-3-pyridinyl}-4-hydroxy-4-[(3R)-3-piperidinyl]butyl}carbamate 
• 1070870-56-2 1,1-dimethylethyl (3R)-3-({5-chloro-4-[3-(1-methylethyl)phenyl]-3-pyridinyl}carbonyl)-1-piperidinecarboxylate 
• 1070870-57-3 1,1-dimethylethyl (3R)-3-(4-amino-1-{5-chloro-4-[3-(1-methylethyl)phenyl]-3-pyridinyl}-1-hydroxybutyl)-1-piperidinecarboxylate 
• 1070870-58-4 1,1-dimethylethyl (3R)-3-(1-{5-chloro-4-[3-(1-methylethyl)phenyl]-3-pyridinyl}-1-hydroxy-4-{[(methyloxy)carbonyl]amino}butyl)-1-piperidinecarboxylate 
• 1426940-31-9 5-(5-(4-fluorobenzo[d]thiazol-2-yl)pyridin-3-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide 

Relevant articles and documents

Logistic flexibility in the preparation of isomeric halopyridinecarboxylic acids

Although there are many conceivable ways to funtionalize, and specifically carboxylate, 2-chloro-4-(trifluoromethyl)pyridine optionally at all three vacant positions, it is more straightforward to prepare only the 2-chloro-4- (trifluoromethyl)pyridine-3-carboxylic acid (1) from this precursor and the other 6-chloro-4-(trifluoromethyl)pyridine-2- and -3-carboxylic acids (2 and 3) from a different one, viz. 5-bromo-2-chloro-4-(trifluoromethyl)pyridine. In the same manner, it proved more convenient to convert 5-chloro-2-(trifluoromethyl) pyridine in only two of the corresponding acids (6 and 7) and to make the third one (8) from 3-bromo-5-chloro-2-(trifluoromethyl)pyridine as an alternative starting material. All model substrates for functionalization were readily accessible from the correspondingly substituted chloroiodopyridine through heavy halogen displacement by in situ generated (trifluoromethyl)copper. Graphical Abstract