736933-69-0Relevant articles and documents
Total synthesis of the hydroxyketone kurasoin A using asymmetric phase-transfer alkylation
Andrus, Merritt B.,Hicken, Erik J.,Stephens, Jeffrey C.,Bedke, D. Karl
, p. 8651 - 8654 (2007/10/03)
The total synthesis of the farnesyltransferase inhibitor kurasoin A has been achieved using a novel asymmetric phase-transfer-catalyzed glycolate alkylation reaction. 2,5-Dimethoxyacetophenone 7 with cinchonidinium catalyst 9 (10 mol %) and hydroxide base
Phase-transfer-catalyzed asymmetric glycolate alkylation
Andrus, Merritt B.,Hicken, Erik J.,Stephens, Jeffrey C.
, p. 2289 - 2292 (2007/10/03)
Asymmetric surrogate glycolate alkylation has been performed under phase-transfer conditions. Diphenylmethyloxy-2,5-dimethoxyacetophenone with trifluorobenzyl cinchonidinium catalyst and cesium hydroxide provided alkylation products at -35°C in high yield