738541-91-8

Basic information

• Product Name: 2-(3-Amino-propyl)-2-phenyl-malonic acid diethyl ester
• Synonyms: 2-(3-Amino-propyl)-2-phenyl-malonic acid diethyl ester
• CAS NO: 738541-91-8
• Molecular Weight: 293.363
• Mol File: 738541-91-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(3-Amino-propyl)-2-phenyl-malonic acid diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-Amino-propyl)-2-phenyl-malonic acid diethyl ester(738541-91-8)
• EPA Substance Registry System: 2-(3-Amino-propyl)-2-phenyl-malonic acid diethyl ester(738541-91-8)

Safety Data

• Hazardous Substances Data: 738541-91-8(Hazardous Substances Data)

Upstream product

• 10444-14-1 Diethyl 2-(2-cyanoethyl)-2-phenylmalonate 

Downstream Products

• 1025954-23-7 2-(3-phenyl-3,4,5,6-tetrahydro-pyridin-2-ylsulfanyl)-malonic acid diethyl ester 
• 133905-15-4 Ethyl 3-phenyl-2-thioxopiperidine-3-carboxylate 
• 1026960-99-5 2-oxo-3-phenyl-piperidine-3-carboxylic acid 
• 35576-17-1 3-Phenylpiperidine-2-thione 
• 51551-56-5 (RS)-3-phenylpiperidin-2-one 

Relevant articles and documents

Influence of ring size on the outcome of sulfide contraction reactions with thiolactams. Isolation of bicyclic ketene S,N-acetals and thioisomuenchnones

Reaction between diethyl bromomalonate and 3-phenylpyrrolidine-2-thione yielded a vinylogous urethane by the Eschenmoser sulfide contraction. However, with 3-substituted piperidine-2-thiones, sulfur was retained in the products, and a range of bicyclic heterocycles, including bicyclic ketene S,N-acetals (2-alkylidene-1,3-thiazolidin-4-ones) and stable thioisomuechnones, was isolated. A novel dimeric ketene S,N-acetal was characterised by X-ray crystallography.