73960-07-3

Basic information

• Product Name: 4-(DIFLUOROMETHOXY)BENZALDEHYDE
• Synonyms: TIMTEC-BB SBB003837;VITAS-BB TBB000651;p-(difluoromethoxy)benzaldehyde;4-(Difluoromethoxy)benzaldehyde 98%;4-(Difluoromethoxy)benzaldehyde98%;BENZALDEHYDE,4-(DIFLUOROMETHOXY);1-(Difluoromethoxy)-4-formylbenzene;4-(DIFLUOROMETHOXY)BENZALDEHYDE
• CAS NO: 73960-07-3
• Molecular Formula: C₈H₆F₂O₂
• Molecular Weight: 172.13
• EINECS: 277-653-5
• Product Categories: Benzaldehyde;Aldehydes;C8;Carbonyl Compounds;Building Blocks;Carbonyl Compounds;Chemical Synthesis;Difluoromethyl;Fluorinated Building Blocks;Organic Building Blocks;Organic Fluorinated Building Blocks;Fluorine series
• Mol File: 73960-07-3.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 222 °C(lit.)
• Flash Point: 228 °F
• Appearance: /
• Density: 1.302 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0522mmHg at 25°C
• Refractive Index: n20/D 1.503(lit.)
• Storage Temp.: Room temperature.
• Sensitive: Air Sensitive
• BRN: 3049286
• CAS DataBase Reference: 4-(DIFLUOROMETHOXY)BENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(DIFLUOROMETHOXY)BENZALDEHYDE(73960-07-3)
• EPA Substance Registry System: 4-(DIFLUOROMETHOXY)BENZALDEHYDE(73960-07-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-37/39-24/25
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 73960-07-3(Hazardous Substances Data)

Usage

Chemical Properties

light yellow liquid

Uses

4-(Difluoromethoxy)benzaldehyde may be used for the preparation of 4-(4-difluoro-methoxy-phen-yl)-1,2,3,4,5,6,7,8-octa-hydro-quinazoline-2,5-dione, via one-pot three-component reaction with cyclo-hexane-1,3-dione and urea.

General Description

4-(Difluoromethoxy)benzaldehyde is a p-difluoromethoxy substituted benzaldehyde.

InChI:InChI=1/C8H6F2O2/c9-8(10)12-7-3-1-6(5-11)2-4-7/h1-5,8H

Upstream product

• 123-08-0 4-hydroxy-benzaldehyde 
• 1895-39-2 sodium chlorodifluoroacetate 
• 1885-46-7 trifluoromethanesulfonic acid difluoromethyl ether 
• 104-88-1 4-chlorobenzaldehyde 
• 87199-17-5 4-formylphenylboronic acid, 
• 115262-01-6 [bromo(difluoro)methyl]-trimethyl-silane 
• 75-45-6 Chlorodifluoromethane 
• 65094-22-6 diethyl (bromodifluoromethyl)phosphonate 

Downstream Products

• 103962-07-8 (E)-3-(4-(difluoromethoxy)phenyl)acrylic acid 
• 127842-68-6 3-(4-difluoromethoxyphenyl)-3-aminopropionic acid 
• 75895-49-7 (4-Difluoromethoxy-phenyl)-hydroperoxy-methanol 
• 84761-72-8 4-(4-Difluoromethoxy-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester 
• 127842-58-4 N-(4-Difluoromethoxy-benzyl)-formamide 
• 84761-71-7 4-(4-Difluoromethoxy-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester 
• 135950-38-8 (2R,3S)-3-<4'-(difluoromethoxy)phenyl>serine 
• 137717-11-4 (2R,3R)-β-(4¹-difluoromethoxyphenyl)serine 
• 1027296-48-5 (E)-3-(4-(difluoromethoxy)phenyl)prop-2-en-1-ol 
• 1622219-79-7 (4-(difluoromethoxy)phenyl)(2-(3,5-difluorophenyl)-1,3-dithian-2-yl)methanol 
• 503132-37-4 4-difluoromethoxy-phenyl benzaldehyde-tosylhydrazone 
• 1437125-13-7 2-((2-((tert-butyldimethylsilyl)oxy)ethyl)(4-(difluoromethoxy)benzyl)amino)ethanol 
• 1437110-70-7 4-(4-(difluoromethoxy)benzyl)-9-nitro-3,4,5,6-tetrahydro-2H-imidazo[2,1-b][1,3,6]oxadiazocine 

Relevant articles and documents

Difluoromethylation of Phenols and Thiophenols with the S-(Difluo-romethyl)sulfonium Salt: Reaction, Scope, and Mechanistic Study

A facile and practical approach for the difluoromethylation of phenols and thiophenols was described. Making use of the recently developed bench-stable S-(difluoromethyl)sulfonium salt as the difluorocarbene precursor, a wide variety of diversely functionalized phenols and thiophenols were readily converted to their corresponding aryl difluoromethyl ethers in good to excellent yields in the presence of lithium hydroxide. Chemoselectivity of various O,S-nucleophiles toward difluorocarbene was systematically studied, suggesting the reactivity order ArS- > RS-, ArO- > ROH > RO-, ArSH, ArOH, RSH.

Nitro imidazole heterocyclic compound and its in the preparation of medicine for treating tuberculosis the application of the

The invention relates to a novel nitroimidazole heterocyclic compound and an application of the nitroimidazole heterocyclic compound in preparation of a medicine for treating tuberculosis. The nitroimidazole heterocyclic compound of the present invention has dual function mechanism, can inhibit the protein synthesis of tuberculosis mycobacterium and synthesis of cell wall mycolic acid, has strong activity on pathogen tuberculosis mycobacterium capable of causing tuberculosis, and has high bioavailability.

SYNTHESIS OF DIFLUOROMETHYL ETHERS AND SULFIDES

The synthesis of difluoromethyl ethers and sulfides with a simple, non-ozone- depleting reagent is described. The difluoromethylation of phenols with this reagent occurs at room temperature within minutes with exceptional functional group tolerance. The mild conditions makes possible tandem processes for the conversion of aryl boronic acids, aryl halides and arenes to difluoromethyl ethers. Mechanistic studies support a reaction pathway involving nucleophilic attack of the phenolate to difluorocarbene.