73978-74-2

Basic information

• Product Name: 6-amino-2,4-dimethoxy-5-nitropyrimidine
• Synonyms: 6-amino-2,4-dimethoxy-5-nitropyrimidine
• CAS NO: 73978-74-2
• Molecular Formula: C₆H₈N₄O₄
• Molecular Weight: 200
• Mol File: 73978-74-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 445.9 °C at 760 mmHg
• Flash Point: 223.5 °C
• Appearance: /
• Density: 1.45 g/cm³
• Vapor Pressure: 3.79E-08mmHg at 25°C
• Refractive Index: 1.59
• CAS DataBase Reference: 6-amino-2,4-dimethoxy-5-nitropyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-amino-2,4-dimethoxy-5-nitropyrimidine(73978-74-2)
• EPA Substance Registry System: 6-amino-2,4-dimethoxy-5-nitropyrimidine(73978-74-2)

Safety Data

• Hazardous Substances Data: 73978-74-2(Hazardous Substances Data)

Usage

General Description

6-amino-2,4-dimethoxy-5-nitropyrimidine is a chemical compound with the molecular formula C7H9N3O4. It is a yellow crystalline solid that is commonly used in the pharmaceutical and agrochemical industries as a building block for the synthesis of various drugs and herbicides. 6-amino-2,4-dimethoxy-5-nitropyrimidine contains an amino group, two methoxy groups, and a nitro group attached to a pyrimidine ring. It has potential applications as an antitumor agent and may also be used in the production of dyes and pigments. Additionally, it has been studied for its potential role in the treatment of various diseases, making it an important compound for medicinal chemistry research.

InChI:InChI=1/C6H8N4O4/c1-13-5-3(10(11)12)4(7)8-6(9-5)14-2/h1-2H3,(H2,7,8,9)

Upstream product

• 6320-15-6 6-chloro-2,4-dimethoxypyrimidine 
• 73978-73-1 4-amino-2,6-dimethoxy-5-nitrosopyrimidine 
• 60331-03-5 4-chloro-2,6-dimethoxy-5-nitropyrimidine 
• 3289-50-7 2,6-dimethoxypyrimidin-4-amine 
• 31221-68-8 2,6-dichloro-5-nitropyrimidin-4-amine 
• 124-41-4 sodium methylate 

Downstream Products

• 73978-84-4 4-methoxy-2-oxo-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-7-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyloxy)-1,2-dihydropteridin 
• 73978-83-3 2,4-Dimethoxy-7-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyloxy)pteridin 
• 73978-86-6 2,4-Dimethoxy-6-methyl-7-oxo-7,8-dihydropteridin 
• 73978-85-5 2,4-Dimethoxy-7-oxo-7,8-dihydropteridin 
• 133185-44-1 5,6-Diamino-2,4-dimethoxypyrimidine 
• 5327-19-5 2,6-dimethoxy-7(9)H-purine 
• 73978-75-3 2,4-Dimethoxy-5-nitro-6-<(2,3,5-tri-O-benzoyl-α-D-ribofuranosyl)amino>pyrimidin 
• 73978-76-4 2,4-Dimethoxy-5-nitro-6-<(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)amino>pyrimidin 

Relevant articles and documents

Hydrogen bonding in nitroaniline analogues: Hydrogen-bonded sheets in 2-amino-4,6-dimethoxy-5-nitropyrimidine and π-stacked hydrogen-bonded sheets in 4-amino-2,6-dimethoxy-5-nitropyrimidine

In 2-amino-4,6-dimethoxy-5-nitropyrimidine, C6H8N4O4, the molecules are linked by one N-H...N and one N-H...O hydrogen bond to form sheets built from alternating R22(8) and R66(32) rings. In isomeric 4-amino-2,6-dimethoxy-5-nitropyrimidine, C6H8N4O4, which crystallizes with Z′ = 2 in P1macr;, the two independent molecules are linked into a dimer by two independent N-H...N hydrogen bonds. These dimers are linked into sheets by a combination of two-centre C-H...O and three-centre C-H...(O)2 hydrogen bonds, and the sheets are further linked by two independent aromatic π-π-stacking interactions to form a three-dimensional structure.

Herbicidal pyridyl sulfonamides

Certain N-[(pyridyl or pyrimidyl)aminocarbonyl]arylsulfonamides, such as the compound methyl 2-[[N-(3-cyano-4,6-dimethylpyridin-2-yl)aminocarbonyl]aminosulfonyl]benzoate, possess herbicidal activity.

Nucleosides, XXXIII. Synthesis of 7-Oxo-8-β-D-ribofuranosyl-7,8-dihydrolumazine and its 6-Methyl Derivative

The synthesis of 7-oxo-8-β-D-ribofuranosyl-7,8-dihydrolumazine (26) and its 6-methyl derivative (28) has been achieved by a ribosylation reaction of 2,4-bis(benzyloxy)- (18) and 2,4-bis(benzyloxy)-6-methyl-7-oxo-7,8-dihydropteridine (19), respectively, un