73981-15-4

Basic information

• Product Name: diethyl 2-benzoyloxypropanedioate
• Synonyms: diethyl 2-benzoyloxypropanedioate;Propanedioic acid, 2-(benzoyloxy)-, 1,3-diethyl ester
• CAS NO: 73981-15-4
• Molecular Formula: C₁₄H₁₆O₆
• Molecular Weight: 280.27
• Mol File: 73981-15-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 393.3°C at 760 mmHg
• Flash Point: 173.4°C
• Appearance: /
• Density: 1.199g/cm³
• Vapor Pressure: 2.15E-06mmHg at 25°C
• Refractive Index: 1.505
• CAS DataBase Reference: diethyl 2-benzoyloxypropanedioate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl 2-benzoyloxypropanedioate(73981-15-4)
• EPA Substance Registry System: diethyl 2-benzoyloxypropanedioate(73981-15-4)

Safety Data

• Hazardous Substances Data: 73981-15-4(Hazardous Substances Data)

Usage

General Description

Diethyl 2-benzoyloxypropanedioate, also known as benzocaine, is a chemical compound commonly used as a local anesthetic and pain reliever. It belongs to the ester class of compounds and is commonly found in over-the-counter products such as throat lozenges, cough drops, and topical pain relief creams. It works by temporarily numbing the skin and mucous membranes, providing relief from minor skin irritations and sore throat discomfort. However, it should be used with caution as it may cause allergic reactions or irritation in some individuals. Additionally, excessive or prolonged use of products containing diethyl 2-benzoyloxypropanedioate may lead to further complications and should be avoided.

InChI:InChI=1/C14H16O6/c1-3-18-13(16)11(14(17)19-4-2)20-12(15)10-8-6-5-7-9-10/h5-9,11H,3-4H2,1-2H3

Upstream product

• 65-85-0 benzoic acid 
• 105-53-3 diethyl malonate 
• 108-88-3 toluene 
• 5256-74-6 1,3-diethyl 2-diazopropanedioate 
• 94-36-0 dibenzoyl peroxide 

Downstream Products

• 111979-83-0 O-Benzoyl-benzoyltartronsaeure-diaethylester 
• 1971-55-7 benzyltartronic acid 
• 80-69-3 tartronic acid 

Relevant articles and documents

C–O bond formation via oxidative-coupling pathway in eutectic mixture of choline chloride/urea as a green solvent

C–O bond formation between terminal alkenes/benzyl alcohols as an arylcarboxy surrogate and carbonyl compounds in a biodegradable deep eutectic solvent (DES) based on choline chloride and urea was performed. By employment of TBAI as catalyst and TBHP as oxidant, various derivatives of carbonyl compounds were benzylated in α position in good to high yield at 90 °C. Moreover, α-oxybenzoylation of diethyl malonate with carboxylic acids was performed in the above-mentioned DES by employment of NaI as the catalyst and TBHP as the oxidant at 60 °C.

Bu4NI-Catalyzed α-Oxyacylation of Carbonyl Compounds with Toluene Derivatives

A TBAI (tetrabutylammonium iodide)-catalyzed direct α-oxyacylation of carbonyl compounds from readily available toluene derivatives has been developed. The distinguished features of this metal-free protocol include the employment of simple starting material, a wide carbonyl compound scope, and mild reaction conditions.