73986-53-5Relevant articles and documents
A PROCESS FOR PREPARATION OF O-DESMETHYLTRAMADOL AND SALTS THEREOF
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Page/Page column 11, (2019/04/11)
The present invention relates to a process of preparation of O-Desmethyl tramadol through potassium hydroxide mediated demethylation of Tramadol under phase transfer conditions.
COMPOSITIONS AND METHODS FOR OVERCOMING RESISTANCE TO TRAMADOL
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Paragraph 0211, (2013/03/26)
There is disclosed a composition for oral administration of O-desmethyltramadol. There is further disclosed a method for treating disorders modulated by at least opiate receptor activity or monoamine activity, including acute and chronic pain, comprising administering a pharmaceutical formulation comprising O-desmethyltramadol. Compositions and methods are also provided that are effective for overcoming resistance to tramadol in patients.