740082-31-9Relevant articles and documents
Synthesis and antagonistic activity at muscarinic receptor subtypes of some derivatives of diphenidol
Varoli, Lucilla,Angeli, Piero,Buccioni, Michela,Burnelli, Silvia,Cavalli, Andrea,Marucci, Gabriella,Recanatini, Maurizio
, p. 651 - 657 (2003)
A series of new derivatives, related to diphenidol and to its 2-carbonyl analogue, were designed as antimuscarinic agents. The synthesized compounds were evaluated both as hydrochlorides and as methiodides by functional tests at guinea-pig heart (M2), guinea-pig ileum (M3) and rabbit vas deferens (putative M4). Two derivatives (3a and 5a) showed an M3-selective profile similar to that of the reference compounds, though they resulted less potent.