7404-63-9

Basic information

• Product Name: 2-Thienylmethylamine hydrochloride
• Synonyms: (2-thienylmethyl)ammonium chloride;2-THIOPHENEMETHYLAMINE HYDROCHLORIDE;2-Thienylmethylamine hydrochloride;Nsc400116
• CAS NO: 7404-63-9
• Molecular Formula: C₅H₇NS*ClH
• Molecular Weight: 149.64172
• EINECS: 231-011-0
• Mol File: 7404-63-9.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 194.5 °C at 760 mmHg
• Flash Point: 73.9 °C
• Appearance: /
• Vapor Pressure: 0.44mmHg at 25°C
• CAS DataBase Reference: 2-Thienylmethylamine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Thienylmethylamine hydrochloride(7404-63-9)
• EPA Substance Registry System: 2-Thienylmethylamine hydrochloride(7404-63-9)

Safety Data

• Hazardous Substances Data: 7404-63-9(Hazardous Substances Data)

Usage

General Description

2-Thienylmethylamine hydrochloride is a chemical compound that is used primarily in laboratory research. It has a molecular formula of C5H7NS·HCl, which indicates that it is made up of carbon, hydrogen, sulfur, and chlorine atoms. The chemical belongs to the category of thiophenes, a type of heterocyclic compound that has sulfur and hydrogen as substituent elements. It's a hydrochloride salt form of 2-thienylmethylamine, serving as an essential reagent in various chemical reactions in laboratory settings. It must be handled with care, as with all chemicals, following specific safety protocols.

InChI:InChI=1/C5H7NS.ClH/c6-4-5-2-1-3-7-5;/h1-3H,4,6H2;1H

Upstream product

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• 5813-89-8 2-thiophenylcarboxamide 
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Downstream Products

• 636-72-6 2-thiophenemethanol 

Relevant articles and documents

Manipulating Color Emission in 2D Hybrid Perovskites by Fine Tuning Halide Segregation: A Transparent Green Emitter

Halide perovskite materials offer an ideal playground for easily tuning their color and, accordingly, the spectral range of their emitted light. In contrast to common procedures, this work demonstrates that halide substitution in Ruddlesden–Popper perovskites not only progressively modulates the bandgap, but it can also be a powerful tool to control the nanoscale phase segregation—by adjusting the halide ratio and therefore the spatial distribution of recombination centers. As a result, thin films of chloride-rich perovskite are engineered—which appear transparent to the human eye—with controlled tunable emission in the green. This is due to a rational halide substitution with iodide or bromide leading to a spatial distribution of phases where the minor component is responsible for the tunable emission, as identified by combined hyperspectral photoluminescence imaging and elemental mapping. This work paves the way for the next generation of highly tunable transparent emissive materials, which can be used as light-emitting pixels in advanced and low-cost optoelectronics.

Metal-Free Synthesis of Heteroaryl Amines or Their Hydrochlorides via an External-Base-Free and Solvent-Free C-N Coupling Protocol

Herein, a metal-free and solvent-free protocol was developed for the C-N coupling of heteroaryl halides and amines, which afforded numerous heteroaryl amines or their hydrochlorides without any external base. Further investigations elucidated that the basicity of amines and specific interactions derived from the X-ray crystallography analysis of 3j′·HCl played pivotal roles in the reactions. Moreover, this protocol was scalable to gram scales and applicable to drug molecules, which demonstrated its practical value for further applications.

Deoxygenation of primary amides to amines with pinacolborane catalyzed by Ca[N(SiMe3)2]2(THF)2

Deoxygenative reduction of amides is a challenging but favorable synthetic method of accessing amines. In the presence of a catalytic amount of Ca[N(SiMe3)2]2(THF)2, pinacolborane (HBpin) could efficiently reduce a broad scope of amides, primary amides in particular, into corresponding amines. Functional groups and heteroatoms showed good tolerance in this process of transformation, and a plausible reaction mechanism was proposed.