74050-97-8

Basic information

• Product Name: 4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]-4-piperidyl decanoate
• Synonyms: 4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]-4-piperidyl decanoate;Decanoic acid, 4-(4-chlorophenyl)-1-4-(4-fluorophenyl)-4-oxobutyl-4-piperidinyl ester;Decanoic acid 4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl ester;Halomonth;KD-136;R-13672;Depot haloperidol;Einecs 277-679-7
• CAS NO: 74050-97-8
• Molecular Formula: C31H41ClFNO3
• Molecular Weight: 530.1135432
• EINECS: 277-679-7
• Product Categories: Organics;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 74050-97-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 615.5 °C at 760 mmHg
• Flash Point: 326.1°C
• Appearance: /
• Density: 1.1074 (estimate)
• Vapor Pressure: 4.38E-15mmHg at 25°C
• Refractive Index: 1.554
• Solubility: Practically insoluble in water, very soluble in ethanol (96 per cent), in methanol and in methylene chloride.
• CAS DataBase Reference: 4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]-4-piperidyl decanoate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]-4-piperidyl decanoate(74050-97-8)
• EPA Substance Registry System: 4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]-4-piperidyl decanoate(74050-97-8)

Safety Data

• RIDADR: 3249
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 74050-97-8(Hazardous Substances Data)

Usage

Uses

Haloperidol Decanoate is an antipsychotic and antidyskinetic agent.

Brand name

Haldol (Ortho-McNeil).

InChI:InChI=1/C31H41ClFNO3/c1-2-3-4-5-6-7-8-11-30(36)37-31(26-14-16-27(32)17-15-26)20-23-34(24-21-31)22-9-10-29(35)25-12-18-28(33)19-13-25/h12-19H,2-11,20-24H2,1H3

Upstream product

• 52-86-8 haloperidol 
• 112-13-0 n-decanoyl chloride 
• 334-48-5 1-decanoic acid 

Relevant articles and documents

Synthesis and binding profile of haloperidol-based bivalent ligands targeting dopamine D2-like receptors

Homodimers of dopamine D2-like receptors are suggested to be of particular importance in the pathophysiology of schizophrenia and, thus, serve as promising targets for the discovery of atypical antipsychotics. This study describes the development of a series of novel bivalent molecules with a pharmacophore derived from the dopamine receptor antagonist haloperidol. These dimers were investigated in comparison to their monomeric analogues for their D2long, D2short, D3, and D4 receptor binding and the ability to bridge two neighboring receptor protomers. Radioligand binding studies provided diagnostic insights when Hill slopes close to two for the bivalent ligand 13 incorporating 22 spacer atoms and a comparative analysis with monovalent control ligands indicated a bivalent binding mode with a simultaneous occupancy of two neighboring binding sites.