740842-86-8

Basic information

• Product Name: 7-BROMO-2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINE
• Synonyms: 7-BROMO-2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINE;7-bromo-2,3,4,5-tetrahydro-1H-3-Benzazepine
• CAS NO: 740842-86-8
• Molecular Formula: C₁₀H₁₂BrN
• Molecular Weight: 226.11298
• Mol File: 740842-86-8.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 7-BROMO-2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-BROMO-2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINE(740842-86-8)
• EPA Substance Registry System: 7-BROMO-2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINE(740842-86-8)

Safety Data

• Hazardous Substances Data: 740842-86-8(Hazardous Substances Data)

Upstream product

• 4133-35-1 6-bromo-2-tetralone 
• 75-75-2 methanesulfonic acid 
• 107393-73-7 2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamine 
• 740842-84-6 7-bromo-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one 

Downstream Products

• 1608496-71-4 C₂₀H₂₃ClN₂ 
• 1608496-70-3 C₂₀H₂₁ClN₂O 
• 1608496-69-0 C₂₀H₂₂N₂O 
• 740842-89-1 tert-butyl 7-bromo-2,3,4,5-tetrahydro-2H-benzo[c]azepine-2-carboxylate 
• 740842-88-0 tert-butyl 7-bromo-1,2,4,5-tetrahydro-3H-benzo[d]azepine-3-carboxylate 

Relevant articles and documents

TETRAHYDRO-BENZOAZEPINE GLYCOSIDASE INHIBITORS

Compounds of formula (I') wherein A, R1, R2, T1, T2, T3, T4, L, W, Z, R''', m and n have the meaning according to the claims can be employed, inter alia, for the treatment of tauopathies and Alzheimer's disease.

TETRAHYDRO-BENZO[D]AZEPINE DERIVATIVES AS GPR120 MODULATORS

Novel tetrahydroisoquinoline and tetrahydrobenzazepine compounds of formula (I) capable of modulating the G-protein-coupled receptor GPR120, compositions comprising the compounds, and methods for their use for controlling insulin levelsin vivoand for the treatment of conditions such as of diabetes, inflammation, obesity and metabolic diseases. (I)

Potent histone deacetylase inhibitors derived from 4-(aminomethyl)-N- hydroxybenzamide with high selectivity for the HDAC6 isoform

A screen for HDAC6 inhibitors identified acyl derivatives of 4-(aminomethyl)-N-hydroxybenzamide as potent leads with unexpected selectivity over the other subtypes. We designed and synthesized constrained heterocyclic analogues such as tetrahydroisoquinolines that show further enhanced HDAC6 selectivity and inhibitory activity in cellular assays. Selectivity may be attributed to the benzylic spacer more effectively accessing the wider channel of HDAC6 compared to other HDAC subtypes as well as hydrophobic capping groups interacting with the protein surface near the rim of the active site.