7409-48-5

Basic information

• Product Name: 2-(Diethylamino)acetamide
• Synonyms: 2-(Diethylamino)acetamide
• CAS NO: 7409-48-5
• Molecular Formula: C₆H₁₄N₂O
• Molecular Weight: 130.1882
• Mol File: 7409-48-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 227.9°Cat760mmHg
• Flash Point: 91.6°C
• Appearance: /
• Density: 0.959g/cm³
• Vapor Pressure: 0.0757mmHg at 25°C
• Refractive Index: 1.459
• CAS DataBase Reference: 2-(Diethylamino)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(Diethylamino)acetamide(7409-48-5)
• EPA Substance Registry System: 2-(Diethylamino)acetamide(7409-48-5)

Safety Data

• Hazardous Substances Data: 7409-48-5(Hazardous Substances Data)

Usage

Type of compound

Tertiary amine and amide

Functional groups

Diethylamino group attached to an acetamide group

Common uses

Key intermediate in the synthesis of pharmaceuticals (e.g. local anesthetics, antiarrhythmic agents), production of UV stabilizers for plastics and rubber, manufacturing of dyes and pigments

Potential applications

Organic synthesis, medicinal chemistry

Interest

Researchers and industry professionals due to its versatile properties and wide range of potential applications.

InChI:InChI=1/C6H14N2O/c1-3-8(4-2)5-6(7)9/h3-5H2,1-2H3,(H2,7,9)

Upstream product

• 683-57-8 bromo-acetic acid amide 
• 109-89-7 diethylamine 
• 7664-93-9 sulfuric acid 
• 52900-90-0 1-diethylamino-butane-2,3-dione-2-oxime ; hydrochloride 
• 79-07-2 Chloroacetamide 

Downstream Products

• 102-54-5 ferrocene 
• 137-58-6 2-diethylamino-N-(2,6-dimethylphenyl)-acetamide 
• 617-83-4 Diethylcyanamide 

Relevant articles and documents

Carborane-derived local anesthetics are isomer dependent

Clinically there is a need for local anesthetics with a greater specificity of action on target cells and longer duration. We have synthesized a series of local anesthetic derivatives we call boronicaines in which the aromatic phenyl ring of lidocaine was replaced with ortho-, meta-,C,C′-dimethyl meta- and para-carborane clusters. The boronicaine derivatives were tested for their analgesic activity and compared with lidocaine using standard procedures in mice following a plantar injection. The compounds differed in their analgesic activity in the following order: ortho-carborane = C,C′-dimethyl meta-carborane > para-carborane > lidocaine > meta-carborane derivative. Both ortho-boronicaine and C,C′-dimethyl meta-boronicaine had longer durations of analgesia than lidocaine. Differences in analgesic efficacies are rationalized by variations in chemical structure and protein binding characteristics.

CLUSTER BORON COMPOUNDS AND USES THEREOF

The present invention relates to novel cluster boron compounds and their use as sodium channel blockers. In particular, the novel cluster boron compounds may be lidocaine analogs where the aromatic ring of the lidocaine molecule is replaced with a cluster boron group.The invention also provides methods for making the cluster boron compounds comprising contacting a halogenated cluster boron with an amino acetamide in the presence of a catalyst, a proton acceptor, and a ligand.