74114-62-8

Basic information

• Product Name: 4-AcetaMido-3-chlorobenzoic acid
• Synonyms: 4-AcetaMido-3-chlorobenzoic acid
• CAS NO: 74114-62-8
• Molecular Formula: C₉H₈ClNO₃
• Molecular Weight: 213.61772
• Mol File: 74114-62-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-AcetaMido-3-chlorobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AcetaMido-3-chlorobenzoic acid(74114-62-8)
• EPA Substance Registry System: 4-AcetaMido-3-chlorobenzoic acid(74114-62-8)

Safety Data

• Hazardous Substances Data: 74114-62-8(Hazardous Substances Data)

Usage

General Description

4-Acetamido-3-chlorobenzoic acid is a chemical compound that consists of an acetamido group, a chloro group, and a benzoic acid group. It is commonly used in pharmaceutical and research applications. 4-AcetaMido-3-chlorobenzoic acid is often studied for its potential medicinal properties, particularly in the treatment of various diseases and conditions. It is also used as a building block in organic synthesis, where it can be modified and transformed into other related compounds. The 4-acetamido-3-chlorobenzoic acid is a versatile and important chemical with various potential uses in the field of medicine and chemistry.

Upstream product

• 2486-71-7 4-amino-3-chlorobenzoic acid 
• 75-36-5 acetyl chloride 
• 615-65-6 2-chloro-4-methyl-benzenamine 
• 556-08-1 p-(acetylamino)benzoic acid 
• 18931-78-7 N-(2-chloro-4-methylphenyl)acetamide 

Downstream Products

• 207992-38-9 N-allyl-2-chloro-4-cyanoacetanilide 
• 53312-88-2 N-(2-chloro-4-cyanophenyl)acetamide 
• 2486-71-7 4-amino-3-chlorobenzoic acid 
• 3460-23-9 N-(4-bromo-2-chlorophenyl)acetamide 

Relevant articles and documents

Inhibitors of caspases

The present invention relates to novel classes of compounds which are caspase inhibitors, in particular interleukin-1β converting enzyme (“ICE”) inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting caspase activity and consequently, may be advantageously used as agents against interleukin-1-(“IL-1”), apoptosis-, interferon-γ inducing factor-(IGIF), or interferon-γ-(“IFN-γ”) mediated diseases, including inflammatory diseases, autoimmune diseases, destructive bone disorders, proliferative disorders, infectious diseases, and degenerative diseases. This invention also relates to methods for inhibiting caspase activity and decreasing IGIF production and IFN-γ production and methods for treating interleukin-1, apoptosis-, and interferon-γ-mediated diseases using the compounds and compositions of this invention. This invention also relates to methods of preparing the compounds of this invention.

SYNTHESIS AND STRUCTURE OF MONOCHLORO DERIVATIVES OF 2-(4-AMINOPHENYL)-5(6)-AMINOBENZIMIDAZOLE

Methods for the production of the monochloro derivatives of 2-(4-aminophenyl)-5(6)-aminobenzimidazole from chloronitrobenzanilides or by the condensation of 1,2,4-triaminobenzene with chloroaminobenzoic acid were investigated.It was established that the nitration of o-chlorobenzanilides takes place selectively in a mixture of acetic acid, acetic anhydride, and chloroform, while the nitration of 4(7)- or 5(6)-chlorobenzimidazoles takes place in sulfuric acid.The effect of the chlorine atoms and the nitro (amino) group on the IR and PMR spectra of the benzanilides and benzimidazoles is determined by their mutual position and by the position in relation of the amide bridge or the condensed imidazole ring.Analysis of the PMR spectra of the chlorodiaminophenylbenzimidazoles indicated that the amino group was localized at position 6 of the benzimidazole ring.