741287-46-7

Basic information

• Product Name: 1-Boc-4-Isopropylpiperazine
• Synonyms: 4-ISOPROPYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-BOC-4-ISOPROPYLPIPERAZINE;tert-butyl 4-propan-2-ylpiperazine-1-carboxylate;tert-Butyl 4-isopropylpiperazine-1-carboxylate
• CAS NO: 741287-46-7
• Molecular Formula: C₁₂H₂₄N₂O₂
• Molecular Weight: 228.33
• Mol File: 741287-46-7.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 285.778 °C at 760 mmHg
• Flash Point: 126.635 °C
• Appearance: /
• Density: 1.002 g/cm³
• Vapor Pressure: 0.003mmHg at 25°C
• Refractive Index: 1.476
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-Boc-4-Isopropylpiperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Boc-4-Isopropylpiperazine(741287-46-7)
• EPA Substance Registry System: 1-Boc-4-Isopropylpiperazine(741287-46-7)

Safety Data

• Hazardous Substances Data: 741287-46-7(Hazardous Substances Data)

Usage

Description

1-Boc-4-Isopropylpiperazine, also known as Boc-IPPA, is a chemical compound with the formula C13H27N3O2. It is an organic compound that is commonly used as a building block in the synthesis of various pharmaceuticals and other organic compounds. Boc-IPPA is a piperazine derivative, and its structure contains a Boc (tert-butoxycarbonyl) protecting group, which is commonly used in organic synthesis to protect reactive functional groups. 1-Boc-4-Isopropylpiperazine has potential applications in medicinal chemistry and drug development due to its ability to modulate biological processes, and it is an important intermediate in the synthesis of various pharmaceuticals. Additionally, Boc-IPPA is also used in the synthesis of materials for various applications in the chemical industry. Overall, 1-Boc-4-Isopropylpiperazine is a versatile chemical compound with valuable applications in organic synthesis and pharmaceutical research.

Uses

Used in Pharmaceutical Industry:
1-Boc-4-Isopropylpiperazine is used as a building block for the synthesis of various pharmaceuticals for its ability to modulate biological processes and serve as an important intermediate in the development of new drugs.
Used in Chemical Industry:
1-Boc-4-Isopropylpiperazine is used in the synthesis of materials for various applications, such as the production of specialty chemicals and other organic compounds.

InChI:InChI=1/C12H24N2O2/c1-10(2)13-6-8-14(9-7-13)11(15)16-12(3,4)5/h10H,6-9H2,1-5H3

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 67-64-1 acetone 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 

Downstream Products

• 88569-66-8 1-methylethylpiperazine dihydrochloride 
• 93126-18-2 PD161645 
• 4318-42-7 1-(1-methylethyl)piperazine 

Relevant articles and documents

Discovery of a Novel Mycobacterial F-ATP Synthase Inhibitor and its Potency in Combination with Diarylquinolines

The F1FO-ATP synthase is required for growth and viability of Mycobacterium tuberculosis and is a validated clinical target. A mycobacterium-specific loop of the enzyme's rotary γ subunit plays a role in the coupling of ATP synthesis within the enzyme complex. We report the discovery of a novel antimycobacterial, termed GaMF1, that targets this γ subunit loop. Biochemical and NMR studies show that GaMF1 inhibits ATP synthase activity by binding to the loop. GaMF1 is bactericidal and is active against multidrug- as well as bedaquiline-resistant strains. Chemistry efforts on the scaffold revealed a dynamic structure activity relationship and delivered analogues with nanomolar potencies. Combining GaMF1 with bedaquiline or novel diarylquinoline analogues showed potentiation without inducing genotoxicity or phenotypic changes in a human embryonic stem cell reporter assay. These results suggest that GaMF1 presents an attractive lead for the discovery of a novel class of anti-tuberculosis F-ATP synthase inhibitors.

NOVEL PROCESSES FOR THE PREPARATION OF CYCLOPROPYL-AMIDE DERIVATIVES

The present invention is directed to novel processes for the preparation of cyclopropyl-amide derivatives, useful for the treatment of disorders and conditions mediated by the histamine receptor.

PYRAZOLE DERIVATIVE

Not available