74129-15-0

Basic information

• Product Name: 2-[(4-BroMophenyl)Methyl]pyridine
• Synonyms: 2-[(4-BroMophenyl)Methyl]pyridine
• CAS NO: 74129-15-0
• Molecular Formula: C₁₂H₁₀BrN
• Molecular Weight: 248.1185
• Mol File: 74129-15-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 324.8°C at 760 mmHg
• Flash Point: 150.2°C
• Appearance: /
• Density: 1.392g/cm³
• Vapor Pressure: 0.000454mmHg at 25°C
• Refractive Index: 1.604
• CAS DataBase Reference: 2-[(4-BroMophenyl)Methyl]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(4-BroMophenyl)Methyl]pyridine(74129-15-0)
• EPA Substance Registry System: 2-[(4-BroMophenyl)Methyl]pyridine(74129-15-0)

Safety Data

• Hazardous Substances Data: 74129-15-0(Hazardous Substances Data)

Usage

Uses

2-[(4-Bromophenyl)methyl]pyridine, is an intermediate in the synthesis of Bromopheniramine Maleate, a derivative of Pheniramine (P297200), used to treat allergic conditions such as hay fever or urticaria.

InChI:InChI=1/C12H10BrN/c13-11-6-4-10(5-7-11)9-12-3-1-2-8-14-12/h1-8H,9H2

Upstream product

• 110-86-1 pyridine 
• 589-15-1 1-bromomethyl-4-bromobenzene 
• 109-04-6 2-bromo-pyridine 

Downstream Products

• 18453-32-2 (4-bromophenyl)(pyridin-2-yl)methanone 
• 86-22-6 brompheniramine 

Relevant articles and documents

Direct Triflylation of Benzylic C—H Bonds with Pyridine as a Directing Group

The first example of benzylic C—H triflylation was accomplished with pyridine as a directing group. The reaction of various 2-benzylpyridines and (CF3SO2)2O in the presence of NEt3 in CH2Cl2 proceeded smoothly to afford the corresponding benzyl triflones in moderate to high yields.

Rapid Mo(CO)6 catalysed one-pot deoxygenation of heterocyclic halo-benzyl alcohols with Lawesson's reagent

A fast and efficient microwave promoted one-pot method for deoxygenation of heterocyclic halo-benzyl alcohols has been developed. The method does not cause dehalogenation of the substrates and provides the deoxygenated products in high yield after only 30 min.