741681-31-2Relevant articles and documents
Emergence of a single solid chiral state from a nearly racemic amino acid derivative
Noorduin, Wim L.,Izumi, Toshiko,Millemaggi, Alessia,Leeman, Michel,Meekes, Hugo,Van Enckevort, Willem J. P.,Kellogg, Richard M.,Kaptein, Bernard,Vlieg, Elias,Blackmond, Donna G.
, p. 1158 - 1159 (2008/09/20)
The evolution of a single chiral solid state is reported for an amino acid derivative starting from a nearly racemic mixture of solid left- and right-handed crystals. Attrition-enhanced dissolution and recrystallization processes based on solubility considerations of the Gibbs-Thomson rule, coupled with solution-phase racemization, drive this near-equilibrium system inexorably to single chirality in the solid phase. Copyright