74316-55-5

Basic information

• Product Name: 5-BROMO-8-METHYL-QUINOLINE
• Synonyms: 5-BROMO-8-METHYL-QUINOLINE
• CAS NO: 74316-55-5
• Molecular Formula: C₁₀H₈BrN
• Molecular Weight: 222.08
• Mol File: 74316-55-5.mol
• Article Data: 22

Chemical Properties

• Melting Point: 37-38 °C
• Boiling Point: 315.7±22.0 °C(Predicted)
• Appearance: /
• Density: 1.488±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.95±0.29(Predicted)
• CAS DataBase Reference: 5-BROMO-8-METHYL-QUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-8-METHYL-QUINOLINE(74316-55-5)
• EPA Substance Registry System: 5-BROMO-8-METHYL-QUINOLINE(74316-55-5)

Safety Data

• Hazardous Substances Data: 74316-55-5(Hazardous Substances Data)

Usage

General Description

5-Bromo-8-methyl-quinoline is a chemical compound with the molecular formula C10H8BrN. It is a heterocyclic compound with a quinoline core structure and a bromine atom at the 5th position and a methyl group at the 8th position. This chemical is commonly used in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is known for its potential as a building block in the development of new drugs and bioactive molecules. Additionally, 5-Bromo-8-methyl-quinoline is also used in research and development activities in the field of medicinal chemistry and chemical biology. Its unique structure and reactivity make it a valuable tool for scientists and researchers in the study and development of new compounds with potential biological activities.

Upstream product

• 39478-78-9 5-bromo-2-methylaniline 
• 56-81-5 glycerol 
• 3054-95-3 acrylaldehyde diethyl acetal 
• 7726-95-6 bromine 
• 611-32-5 8-methylquinoline 

Downstream Products

• 74316-57-7 8-methylquinoline-5-carbonitrile 
• 1575701-49-3 N-[(5-bromoquinolin-8-yl)methyl]-4-methylbenzenesulfonamide 
• 1197331-55-7 5-(2,6-dichloro-3,5-dimethoxy-phenyl)-quinoline-8-carboxylic acid [4-(4-ethyl-piperazin-1-yl)-phenyl]-amide 
• 1197333-38-2 5-(2,6-difluoro-3,5-dimethoxy-phenyl)-quinoline-8-carboxylic acid ethyl ester 
• 1197333-41-7 5-(2-chloro-6-fluoro-3,5-dimethoxy-phenyl)-quinoline-8-carboxylic acid ethyl ester 
• 1197333-35-9 5-(2,6-dichloro-3,5-dimethoxy-phenyl)-quinoline-8-carboxylic acid 
• 1197333-40-6 5-(2-chloro-6-fluoro-3,5-dimethoxy-phenyl)-quinoline-8-carboxylic acid 
• 1197333-42-8 5-(2-fluoro-3,5-dimethoxy-phenyl)-quinoline-8-carboxylic acid ethyl ester 
• 1197333-39-3 5-(3,5-dimethoxy-phenyl)-quinoline-8-carboxylic acid ethyl ester 
• 1197333-36-0 5-(3,5-dimethoxy-phenyl)-quinoline-8-carboxylic acid 

Relevant articles and documents

Three-Component Couplings among Heteroarenes, Difluorocyclopropenes, and Water via C-H Activation

Three-component couplings have been realized for efficiently constructing various nitrogen-containing skeletons via C-H activation, where difluorocyclopropenes have been first identified as coupling partners. Many substrates including sp2 and sp3 C-H substrates were well tolerated, furnishing the corresponding products in good yields. Furthermore, a catalyst-dependent reaction was also developed, enabling divergent construction of two different frameworks. The application value of these reactions was demonstrated in gram-scale experiments with as little as 1 mol % catalyst.

1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS

Compounds according to formula I are useful as agonists of Toll-like receptor 7 (TLR7). Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.

Palladium-Catalyzed C-H Bond Functionalization Reactions Using Phosphate/Sulfonate Hypervalent Iodine Reagents

A new and operationally simple approach for palladium-catalyzed C-H functionalization reactions utilizing an organophosphorus/sulfonate hypervalent iodine reagent as both an oxidant and the source of a functional group has been developed. Through this method, the oxidative phosphorylation-, sulfonation-, and hydroxylation of unactivated benzyl C(sp3)-H bonds, along with the hydroxylation and arylation of aryl C(sp2)-H bonds, are successfully realized under mild conditions and with excellent site-selectivity. The versatile C-OSO2R bond provides a platform for a wide array of subsequent diversification reactions.