74420-16-9

Basic information

• Product Name: 1H-Pyrrolo[2,3-b]pyridine-3-carboxamide(9CI)
• Synonyms: 1H-Pyrrolo[2,3-b]pyridine-3-carboxamide(9CI);1H-Pyrrolo[2,3-b]pyridine-3-carboxamide
• CAS NO: 74420-16-9
• Molecular Formula: C8H7N3O
• Molecular Weight: 161.16
• Product Categories: AMIDE
• Mol File: 74420-16-9.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Density: 1.416 g/cm³
• Refractive Index: 1.733
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1H-Pyrrolo[2,3-b]pyridine-3-carboxamide(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrolo[2,3-b]pyridine-3-carboxamide(9CI)(74420-16-9)
• EPA Substance Registry System: 1H-Pyrrolo[2,3-b]pyridine-3-carboxamide(9CI)(74420-16-9)

Safety Data

• Hazardous Substances Data: 74420-16-9(Hazardous Substances Data)

Usage

General Description

1H-Pyrrolo[2,3-b]pyridine-3-carboxamide(9CI), also known as AG-490, is a chemical compound that belongs to the pyrrolopyridine class. It is a potent inhibitor of the Janus kinase 2 (JAK2) enzyme, which plays a key role in the signaling pathways of various cytokines and growth factors. By inhibiting JAK2, AG-490 has shown potential in the treatment of conditions such as cancer, inflammation, and autoimmune diseases. It has been studied for its anti-proliferative and anti-inflammatory effects, making it a promising candidate for the development of new therapeutic drugs. AG-490 has gained attention in the field of pharmaceutical research due to its potential in targeting JAK2-related diseases and its ability to modulate cellular responses to cytokines and growth factors.

InChI:InChI=1/C8H7N3O/c9-7(12)6-4-11-8-5(6)2-1-3-10-8/h1-4H,(H2,9,12)(H,10,11)

Upstream product

• 4414-89-5 1H-pyrrolo[2,3-b]pyridine-3-carbonitrile 
• 271-63-6 7-Azaindole 
• 163220-69-7 2,2,2-trichloro-1-(1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone 

Relevant articles and documents

ROCK inhibitors 4: Structure-activity relationship studies of 7-azaindole-based rho kinase (ROCK) inhibitors

Rho kinase (ROCK) inhibitors are of therapeutic value for the treatment of disorders such as hypertension and glaucoma, and potentially of wider use against diseases such as cancer and multiple sclerosis. We previously reported a series of potent and selective ROCK inhibitors based on a substituted 7-azaindole scaffold. Here we extend the SAR exploration of the 7-azaindole series to identify leads for further evaluation. New compounds such as 16, 17, 19, 21 and 22 showed excellent ROCK potency and protein kinase A (PKA) selectivity, combined with microsome and hepatocyte stability.

3-[4-(1H-indol-3-yl)-1,3-thiazol-2-yl]-1H-pyrrolo[2,3-b]pyridines, nortopsentin Analogues with antiproliferative activity

A new series of nortopsentin analogues, in which the imidazole ring of the natural product was replaced by thiazole and the indole unit bound to position 2 of the thiazole ring was substituted by a 7-azaindole moiety, was efficiently synthesized. Two of t

AZAINDOLES USEFUL AS INHIBITORS OF ROCK AND OTHER PROTEIN KINASES

The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.