745052-97-5

Basic information

• Product Name: ethyl 2-(4-cyclopropanesulfonyl-phenyl)-3-(tetrahydropyran-4-yl)propionate
• Synonyms: ethyl 2-(4-cyclopropanesulfonyl-phenyl)-3-(tetrahydropyran-4-yl)propionate
• CAS NO: 745052-97-5
• Molecular Weight: 366.478
• Mol File: 745052-97-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: ethyl 2-(4-cyclopropanesulfonyl-phenyl)-3-(tetrahydropyran-4-yl)propionate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(4-cyclopropanesulfonyl-phenyl)-3-(tetrahydropyran-4-yl)propionate(745052-97-5)
• EPA Substance Registry System: ethyl 2-(4-cyclopropanesulfonyl-phenyl)-3-(tetrahydropyran-4-yl)propionate(745052-97-5)

Safety Data

• Hazardous Substances Data: 745052-97-5(Hazardous Substances Data)

Upstream product

• 101691-94-5 4-(iodomethyl)tetrahydro-2H-pyran 
• 1058167-40-0 ethyl [4-(cyclopropylsulfonyl)phenyl]acetate 
• 132291-95-3 4-(methanesulfonyloxymethyl)tetrahydropyran 
• 14774-37-9 (tetrahydro-2H-pyran-4-yl)methanol 
• 1058167-39-7 ethyl 2-(4-(cyclopropylthio)phenyl)acetate 
• 14633-54-6 cyclopropylphenylsulfide 
• 745052-96-4 ethyl 2-(4-(cyclopropylsulfonyl)phenyl)-3-(tetrahydro-2H-pyran-4-yl)acrylate 
• 101691-65-0 toluene-4-sulfonic acid tetrahydropyran-4-ylmethyl ester 
• 745052-94-2 ethyl 2-(4-cyclopropylsulfanylphenyl)-2-oxoacetate 

Downstream Products

• 745053-49-0 (R)-2-(4-(cyclopropylsulfonyl)phenyl)-3-(tetrahydro-2H-pyran-4-yl)propanoic acid 
• 745052-93-1 2-[4-(cyclopropylsulfonyl)phenyl]-3-(tetrahydro-2H-pyran-4-yl)propionic acid 

Relevant articles and documents

Scalable synthesis of a nonracemic α-arylpropionic acid via ketene desymmetrization for a glucokinase activator

Process research and development for a synthesis of the chiral carboxylic acid (R)-2 as a key intermediate of the glucokinase activator (R)-1 is described. The construction of the stereocenter at the α-carbon is a key point for the synthesis of (R)-2. The proposed process utilizes desymmetrization of a ketene in situ generated from the corresponding racemic carboxylic acid Rac-2 with (R)-pantolactone as a chiral auxiliary followed by hydrolysis of the resulting ester. This key step has been successfully scaled up to 20 kg, which demonstrates that this synthetic approach is comparable with a previously reported approach via enantioselective hydrogenation.

TRICYCLO SUBSTITUTED AMIDES

Compounds of Formula (I) or pharmaceutically acceptable salts thereof, are useful in the prophylactic and therapeutic treatment of hyperglycemia and diabetes.