7454-99-1

Basic information

• Product Name: 6-Methyl-3-propyluracil
• Synonyms: 6-Methyl-3-propyl-2,4(1H,3H)-pyrimidinedione;6-Methyl-3-propyluracil
• CAS NO: 7454-99-1
• Molecular Formula: C8H12N2O2
• Molecular Weight: 168.1931
• Mol File: 7454-99-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.107g/cm³
• Refractive Index: 1.489
• CAS DataBase Reference: 6-Methyl-3-propyluracil(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Methyl-3-propyluracil(7454-99-1)
• EPA Substance Registry System: 6-Methyl-3-propyluracil(7454-99-1)

Safety Data

• Hazardous Substances Data: 7454-99-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H12N2O2/c1-3-4-10-7(11)5-6(2)9-8(10)12/h5H,3-4H2,1-2H3,(H,9,12)

Upstream product

• 6328-58-1 6-methyl-2-methylsulfanyl-3H-pyrimidin-4-one 
• 106-94-5 propyl bromide 
• 626-48-2 6-Methyluracil 
• 107-08-4 1-iodo-propane 
• 31111-31-6 6-methyl-2,4-bis(trimethylsiloxy)pyrimidine 
• 627-06-5 n-propylurea 
• 141-97-9 ethyl acetoacetate 

Downstream Products

• 548942-89-8 5-nitro-1,3-dipropyl-6-styryluracil 
• 157119-69-2 6-Phenyl-1,3-dipropyl-1,5-dihydro-pyrrolo[3,2-d]pyrimidine-2,4-dione 

Relevant articles and documents

PYRROLO[3,2-D]PYRIMIDINES THAT ARE SELECTIVE ANTAGONISTS OF A2B ADENOSINE RECEPTORS

The present invention provides compounds of the following formula and pharmaceutical compositions that are selective antagonists of A2B adenosine receptors (ARs). These compounds and compositions are useful as pharmaceutical agents.

Synthesis and structure-activity relationships of deazaxanthines: Analogs of potent A1- and A2-adenosine receptor antagonists

A set of 22 9-deazaxanthines (pyrrolo[3,2-d]pyrimidine-2,4-diones) and three 7-deazaxanthines (pyrrolo[2,3-d]pyrimidine-2,4-diones) with various substituents in the 1-, 3-, 7- or 9-, and 8-positions was synthesized and investigated in A1 and A2a adenosine receptor binding assays at rat brain cortical membranes and rat brain striatal membranes, respectively. 9- Deazaxanthines showed structure-activity relationships that were similar to those of xanthines. They were about equipotent to the corresponding xanthines at A2a adenosine receptors. 9-Deazaxanthines were generally at least 1-3- fold more potent than xanthines at A1 receptors and therefore exhibited higher A1 selectivities compared to the xanthines. 1,3-Dimethyl-8-(2- naphthyl)-9-deazaxanthine (19e) showed high affinity (K(i) = 26 nM) and selectivity for A1 adenosine receptors. A hydroxyl function at N7 of 9- deazaxanthines was unfavorable for A1 and A2a receptor binding. 7- Deazaxanthines were considerably less potent compared to xanthines and to 9- deazaxanthines at both receptor subtypes.