745784-04-7

Basic information

• Product Name: 3,5-Difluoropicolinic acid
• Synonyms: 3,5-Difluoropicolinic acid;2-Pyridinecarboxylicacid,3,5-difluoro-(9CI);3,5-Difluoropyridine-2-carboxylic acid;3,5-difluoropyridine-2-carbxylic acid;3,5-Difluoropicolinic acid, 2-Carboxy-3,5-difluoropyridine
• CAS NO: 745784-04-7
• Molecular Formula: C₆H₃F₂NO₂
• Molecular Weight: 159.09
• Product Categories: HALIDE;GLYCINESCAFFOLD;CARBOXYLICACID;Pyridine series;Carboxylic Acids;Pyridines;Carboxylic Acids;Building Blocks;Pyridine;C6;Chemical Synthesis;Fluorinated Building Blocks;Heterocyclic Building Blocks;Heterocyclic Fluorinated Building Blocks;Other Fluorinated Heterocycles
• Mol File: 745784-04-7.mol
• Article Data: 1

Chemical Properties

• Melting Point: 202-204°C
• Boiling Point: 240.6 °C at 760 mmHg
• Flash Point: 99.3 °C
• Appearance: /
• Density: 1.535 g/cm³
• Vapor Pressure: 0.0204mmHg at 25°C
• Refractive Index: 1.515
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 2.65±0.10(Predicted)
• CAS DataBase Reference: 3,5-Difluoropicolinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Difluoropicolinic acid(745784-04-7)
• EPA Substance Registry System: 3,5-Difluoropicolinic acid(745784-04-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 745784-04-7(Hazardous Substances Data)

Usage

General Description

3,5-Difluoropicolinic acid is a chemical compound with the molecular formula C6H3F2NO2. It is a derivative of picolinic acid and contains two fluorine atoms attached to the third and fifth carbon atoms of the picolinic acid molecule. 3,5-Difluoropicolinic acid is used in the synthesis and development of pharmaceuticals and agrochemicals. It is also utilized in research and development as a building block for the creation of new chemical compounds with potential biological activities. The presence of fluorine atoms in 3,5-Difluoropicolinic acid makes it a valuable tool in drug discovery and chemical biology, as fluorine substitution is known to alter the physicochemical and pharmacokinetic properties of molecules, potentially leading to improved drug candidates.

InChI:InChI=1/C6H3F2NO2/c7-3-1-4(8)5(6(10)11)9-2-3/h1-2H,(H,10,11)

Upstream product

• 298709-29-2 3,5-difluoropyridine-2-carbonitrile 

Downstream Products

• 1046858-35-8 4-(2,4-dichlorophenyl)-6-[(3,5-difluoropyridin-2-yl)carbonyl]-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-amine 
• 1357143-36-2 [4-(benzyloxy)phenyl](3,5-difluoropyridin-2-yl)methanone 
• 1357143-37-3 4-(1-ethyl-6-fluoro-1H-pyrazolo[4,3-b]pyridin-3-yl)phenol 
• 1357143-53-3 3-[4-(benzyloxy)phenyl]-6-fluoro-1H-pyrazolo[4,3-b]pyridine 
• 1357143-43-1 3-[4-(benzyloxy)phenyl]-6-fluoro-1-(1-methylethyl)-1H-pyrazolo[4,3-b]pyridine 
• 1357143-44-2 4-[6-fluoro-1-(1-methylethyl)-1H-pyrazolo[4,3-b]pyridin-3-yl]phenol 
• 1357143-50-0 4-(6-fluoro-1-methyl-1H-pyrazolo[4,3-b]pyridin-3-yl)phenol 
• 1357143-54-4 4-[1-(2,2-difluoroethyl)-6-fluoro-1H-pyrazolo[4,3-b]pyridin-3-yl]phenol 
• 1361570-34-4 6-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]-3-nitropyridin-2-amine 
• 1361570-35-5 6-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyridine-2,3-diamine 
• 943636-84-8 C₂₇H₂₉F₂N₅O₄ 
• 745784-03-6 3,5-difluoropyridine amide 

Relevant articles and documents

SULFUR-CONTAINING HETEROCYCLIC DERIVATIVE HAVING ?-SECRETASE-INHIBITING ACTIVITY

The following compound is provided as an agent for treating a disease induced by production, secretion and/or deposition of amyloid β protein, for example,. a compound represented by the formula (I): wherein ruing A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group, R1 is optionally substituted lower alkyl or the like, R2a and R2b are each independently hydrogen, optionally substituted lower alkyl or the like, R3a and R3c are each independently hydrogen, halogen, hydroxy, optionally substituted lower alkyl or the like, or a pharmaceutically acceptable salt thereof, or a solvate thereof.