74587-12-5

Basic information

• Product Name: 3-IODO-4-METHOXYANILINE
• Synonyms: 3-IODO-4-METHOXYANILINE;4-Amino-2-iodoanisole;3-Iodo-p-anisidine;4-Amino-2-iodoanisole, 3-Iodo-p-anisidine;3-Iodo-4-methoxybenzenamine;4-AMino-2-iodoanisole[3-Iodo-4-Methoxyaniline];BenzenaMine,3-iodo-4-Methoxy-;(3-iodo-4-methoxyphenyl)amine hydrochloride
• CAS NO: 74587-12-5
• Molecular Formula: C₇H₈INO
• Molecular Weight: 249.05
• Product Categories: Anilines, Aromatic Amines and Nitro Compounds;Anilines, Amides & Amines;Anisoles, Alkyloxy Compounds & Phenylacetates;Iodine Compounds
• Mol File: 74587-12-5.mol
• Article Data: 7

Chemical Properties

• Melting Point: 74 °C
• Boiling Point: 321℃
• Flash Point: 148℃
• Appearance: /
• Density: 1.807
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.647
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility: soluble in Methanol
• PKA: 4.24±0.10(Predicted)
• CAS DataBase Reference: 3-IODO-4-METHOXYANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-IODO-4-METHOXYANILINE(74587-12-5)
• EPA Substance Registry System: 3-IODO-4-METHOXYANILINE(74587-12-5)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 74587-12-5(Hazardous Substances Data)

Usage

General Description

3-Iodo-4-methoxyaniline, also known as 3-iodo-4-methoxyaniline, is a chemical compound with the molecular formula C7H8INO. It belongs to the class of organic compounds known as anilines, which are aromatic amines derived from benzene. This chemical is a pink to brown solid at room temperature and is commonly used as an intermediate in the production of dyes, pharmaceuticals, and other organic compounds. It is also used in the synthesis of fine chemicals and as a building block in the creation of various complex organic molecules. 3-Iodo-4-methoxyaniline is known to have some potential health hazards and should be handled with caution in a controlled laboratory setting.

InChI:InChI=1/C7H8INO/c1-10-7-3-2-5(9)4-6(7)8/h2-4H,9H2,1H3

Upstream product

• 5399-03-1 2-iodo-1-methoxy-4-nitrobenzene 
• 7732-18-5 water 
• 7553-56-2 iodine 
• 104-94-9 4-methoxy-aniline 
• 90-04-0 2-methoxy-phenylamine 
• 529-28-2 4-iodoanisol 
• 100-17-4 para-methoxynitrobenzene 

Downstream Products

• 103796-37-8 3-iodo-4-methoxy-N,N-dimethyl-aniline 
• 104-94-9 4-methoxy-aniline 
• 876341-31-0 tert-butyl 4-[4-(3-iodo-4-methoxyphenylamino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-3,6-dihydro-2H-pyridine-1-carboxylate 

Relevant articles and documents

AMINE-SUBSTITUTED HETEROCYCLIC COMPOUNDS AS EHMT2 INHIBITORS, SALTS THEREOF, AND METHODS OF SYNTHESIS THEREOF

The present disclosure relates to amine-substituted heterocyclic compounds. The present disclosure also relates to pharmaceutical compositions containing these compounds and methods of treating a disorder (e.g., cancer) by administering an amine-substituted heterocyclic heterocyclic compound disclosed herein or a pharmaceutical composition thereof to subjects in need thereof. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.

HETEROCYCLIC COMPOUNDS

The present invention provides a compound represented by the formula (I) wherein each symbol is as defined in the specification, or a salt thereof has an BET family protein inhibitory action, and is useful as an agent for the prophylaxis or treatment of autoimmune diseases and/or inflammatory diseases (e.g., rheumatoid arthritis, multiple sclerosis, idiopathic pulmonary fibrosis, psoriasis, atopic dermatitis, inflammatory bowel disease, Sjogren's syndrome, Behcet's disease, systemic lupus erythematosus etc.), cancer and the like.

Electrochemical C-H amination: Synthesis of aromatic primary amines via N -arylpyridinium ions

We have developed a new method for C-H amination of aromatic compounds based on electrochemical oxidation of aromatic compounds in the presence of pyridine followed by the reaction of the resulting N-arylpyridinium ions with an alkylamine. This new transformation serves as a powerful method for synthesizing aromatic primary amines from aromatic compounds without using metal catalysts and harsh chemical reagents. High chemoselectivity of the present method is demonstrated by C-H amination of aromatic compounds bearing a nitro group to give a key intermediate for the synthesis of VLA-4 antagonist.