7464-48-4

Basic information

• Product Name: 4-Methoxybenzoic acid cyclohexyl ester
• Synonyms: 4-Methoxybenzoic acid cyclohexyl ester
• CAS NO: 7464-48-4
• Molecular Formula: C₁₄H₁₈O₃
• Molecular Weight: 234.2909
• Mol File: 7464-48-4.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 347.7 °C at 760mmHg
• Flash Point: 144.4 °C
• Appearance: /
• Density: 1.1 g/cm³
• Vapor Pressure: 5.29E-05mmHg at 25°C
• Refractive Index: 1.527
• CAS DataBase Reference: 4-Methoxybenzoic acid cyclohexyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methoxybenzoic acid cyclohexyl ester(7464-48-4)
• EPA Substance Registry System: 4-Methoxybenzoic acid cyclohexyl ester(7464-48-4)

Safety Data

• Hazardous Substances Data: 7464-48-4(Hazardous Substances Data)

Usage

General Description

4-Methoxybenzoic acid cyclohexyl ester, also known as methyl 4-methoxybenzoate, is a chemical compound with the molecular formula C14H16O3. It is a colorless liquid with a sweet, floral odor and is commonly used as a fragrance ingredient in the cosmetic and personal care industry. It is also used as a flavoring agent in food products. The compound is also known for its potential antifungal and antibacterial properties. Additionally, it has been studied for its potential use in pharmaceutical applications, such as in the development of new drugs and formulations. Overall, 4-Methoxybenzoic acid cyclohexyl ester has a range of industrial and commercial uses due to its unique properties and potential benefits.

InChI:InChI=1/C14H18O3/c1-16-12-9-7-11(8-10-12)14(15)17-13-5-3-2-4-6-13/h7-10,13H,2-6H2,1H3

Upstream product

• 100-09-4 4-methoxybenzoic acid 
• 108-93-0 cyclohexanol 
• 123-11-5 4-methoxy-benzaldehyde 
• 6712-20-5 2-(4-methoxyphenyl)-[1,3]dithiolane 
• 201230-82-2 carbon monoxide 
• 459-64-3 4-methoxybenzenediazonium tetrafluoroborate 
• 937-29-1 4-methoxybenzoyl bromide 
• 696-62-8 para-iodoanisole 
• 104-88-1 4-chlorobenzaldehyde 
• 100-07-2 4-methoxy-benzoyl chloride 
• 3400-22-4 4-methoxy-N-methylbenzamide 
• 110-83-8 cyclohexene 
• 286-20-4 cyclohexene oxide 
• 105-13-5 4-Methoxybenzyl alcohol 

Relevant articles and documents

Hydroesterification and difunctionalization of olefins with N-hydroxyphthalimide esters

Irradiation of aryl esters of N-hydroxyphthalimides in the presence of unactivated olefins promotes a mild and regioselective hydroesterification. Optimal results are obtained with the aid of fac-Ir(dFppy)3 in CH2Cl2. Terminal and 1,1-disubstituted olefins provide primary esters, and trisubstituted olefins provide secondary esters. The anti-Markovnikov selectivity is consistent with alkyl radical intermediates, which are also indicated by the formation of cyclized products from dienes. Monoacylated diols are formed from trisubstituted and tetrasubstituted olefins in the presence of water.

Synthesis of Unsymmetrical N-Heterocyclic Carbene-Nitrogen-Phosphine Chelated Ruthenium(II) Complexes and Their Reactivity in Acceptorless Dehydrogenative Coupling of Alcohols to Esters

Two novel ruthenium complexes RuH(CO)Cl(PPh3)(κ2-CP) (1) and [fac-RuH(CO)(PPh3)(κ3-CNP)]Cl (2) bearing unsymmetrical N-heterocyclic carbene-nitrogen-phosphine (CNP) were synthesized and characterized with 1H NMR, 31P NMR, and HRMS. The structure of complex 2 was further confirmed by single-crystal X-ray diffraction. An anion exchange experiment proved that complex 2 could transform into complex 1 in solution. The two complexes exhibited a highly catalytic performance in acceptorless dehydrogenative coupling of alcohols to esters, and the excellent isolated yields of esters were given in a catalyst loading of 1% for para- and meta-substituted benzyl alcohols and long-chain primary alcohols. Although some ortho-substituted benzyl alcohols displayed a relatively low reactivity due to the steric hindrance and the coordination of electron donor with the ruthenium center, the good product yields were still obtained by prolonging the reaction time. Especially, this system successfully realized the dehydrogenative cross-coupling to esters between two different primary alcohols.

Highly Active Manganese-Mediated Acylation of Alcohols with Acid Chlorides or Anhydrides

To explore further the practical uses of highly active manganese (Mn?), a variety of alcohols were treated with Mn?, and the resulting complexes were coupled with acid chlorides and/or acetic anhydride in the absence of any extra catalyst. The subsequent reactions took place smoothly under mild conditions, providing the corresponding O-acylation products in good to excellent isolated yields.