74641-30-8

Basic information

• Product Name: meso-1,2-Bis(4-chlorophenyl)ethylenediamine
• Synonyms: (1R,2R)-rel-1,2-Bis(4-chlorophenyl)-(1,2-ethanediamine meso-1,2-bis(4-chlorophen;1,2-BIS(4-CHLOROPHENYL)ETHANE-1,2-DIAMINE;Meso-1,2-Bis(4-chlorophenyl)ethylenediaMine,Min.98%;meso-1,2-Bis(4-chlorophenyl)ethylenediamine
• CAS NO: 74641-30-8
• Molecular Formula: C₁₄H₁₄Cl₂N₂
• Molecular Weight: 281.18036
• Product Categories: organic amine;Achiral Nitrogen;DPEN Series
• Mol File: 74641-30-8.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 418.6 °C at 760 mmHg
• Flash Point: 206.9 °C
• Appearance: white to yellow/Powder
• Density: 1.303 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Storage Temp.: 2-8°C(protect from light)
• PKA: 9.32±0.10(Predicted)
• Sensitive: air sensitive
• CAS DataBase Reference: meso-1,2-Bis(4-chlorophenyl)ethylenediamine(CAS DataBase Reference)
• NIST Chemistry Reference: meso-1,2-Bis(4-chlorophenyl)ethylenediamine(74641-30-8)
• EPA Substance Registry System: meso-1,2-Bis(4-chlorophenyl)ethylenediamine(74641-30-8)

Safety Data

• Hazardous Substances Data: 74641-30-8(Hazardous Substances Data)

Usage

Description

meso-1,2-Bis(4-chlorophenyl)ethylenediamine is an organic compound that serves as a key reactant in the synthesis of various chemical compounds. It is characterized by its unique structure, which includes two 4-chlorophenyl groups attached to a central ethylenediamine moiety. This structure endows it with specific chemical properties that make it suitable for use in the synthesis of bioactive compounds.

Uses

Used in Pharmaceutical Industry:
meso-1,2-Bis(4-chlorophenyl)ethylenediamine is used as a reactant in the synthesis of sinomenine derivatives, which are known for their potent TNF-α inhibitory activity. TNF-α (tumor necrosis factor-alpha) is a cytokine involved in systemic inflammation and is implicated in various inflammatory and autoimmune diseases. By inhibiting TNF-α, sinomenine derivatives can potentially be used for the treatment of such conditions.
In the synthesis process, meso-1,2-Bis(4-chlorophenyl)ethylenediamine plays a crucial role in the formation of the desired sinomenine derivatives, contributing to their biological activity and therapeutic potential. Its unique structure allows for the creation of compounds with specific binding affinities and selectivity, which can be further optimized for improved efficacy and safety in pharmaceutical applications.

InChI:InChI=1/C14H14Cl2N2/c15-11-5-1-9(2-6-11)13(17)14(18)10-3-7-12(16)8-4-10/h1-8,13-14H,17-18H2/p+2/t13-,14+

Upstream product

• 3848-36-0 4-chlorobenzaldoxime 
• 104-88-1 4-chlorobenzaldehyde 
• 41097-37-4 (1E, 2E)-1,2-bis (4-chlorobenzylidene) hydrazine 
• 115294-32-1 4-chloro-benzoic acid-[erythro-4,4'-dichloro-α'-(4-chloro-benzylidenamino)-bibenzyl-α-ylamide] 

Downstream Products

• 1582815-27-7 (1S,2R)-N-2-amino-1,2-bis(4-chlorophenyl)ethylallyl carbamate 
• 1353891-92-5 N-((1S,2R)-2-amino-1,2-bis(4-chlorophenyl)ethyl)-2-isopropoxy-4-methoxybenzamide 
• 1353891-93-6 N-((1R,2S)-1,2-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxybenzamido)ethyl)-3-oxopiperazine-1-carboxamide 
• 548472-68-0 nutlin-3a 
• 1353891-88-9 tert-butyl ((1R,2S)-2-amino-1,2-bis(4-chlorophenyl)ethyl)carbamate 
• 1353891-90-3 tert-butyl (1R,2S)-1,2-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxybenzamido)ethylcarbamate 

Relevant articles and documents

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The invention provides dimer amide micromolecule PROTACs for inducing MDM2 to self-degrade E3 ubiquitin ligase. The structure of the PROTACs is shown in the specification, wherein in a compound (I), L1 is C1-C30 linear or branched alkyl with or without a substituent group, and any carbon atom in L1 is optionally replaced by heteroatom; R1, R2, R3 and R4 are C1-C30 linear or branched alkyl with orwithout a substituent group, C1-C30 aryl with or without a substituent group, C1-C30 linear or branched alkylaryl with or without a substituent group or C1-C30 linear or branched aryl alkyl with or without a substituent group respectively and independently; X1, X2, X3 and X4 are halogen respectively and independently.