7471-72-9

Basic information

• Product Name: 4-chloro-9-methoxy-7H-furo[3,2-g]chromen-7-one
• Synonyms: 4-Chloro-9-methoxy-7H-furo(3,2-g)chromen-7-one; 4-Chloro-9-methoxy-7H-furo[3,2-g]chromen-7-one; 7H-furo[3,2-g][1]benzopyran-7-one, 4-chloro-9-methoxy-
• CAS NO: 7471-72-9
• Molecular Formula: C₁₂H₇ClO₄
• Molecular Weight: 250.6346
• Mol File: 7471-72-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 446.7°C at 760 mmHg
• Flash Point: 224°C
• Density: 1.474g/cm³
• Vapor Pressure: 3.57E-08mmHg at 25°C
• Refractive Index: 1.643
• CAS DataBase Reference: 4-chloro-9-methoxy-7H-furo[3,2-g]chromen-7-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-9-methoxy-7H-furo[3,2-g]chromen-7-one(7471-72-9)
• EPA Substance Registry System: 4-chloro-9-methoxy-7H-furo[3,2-g]chromen-7-one(7471-72-9)

Safety Data

• Hazardous Substances Data: 7471-72-9(Hazardous Substances Data)

Upstream product

• 298-81-7 9-methoxy-7H-furo[3,2-g][1]benzopyran-7-one 
• 1930-56-9 4-nitro-9-methoxy-7H-furo<3,2-g><1>benzopyran-7-one 
• 7647-01-0 hydrogenchloride 
• 64-17-5 ethanol 
• 67-56-1 methanol 
• 49739-65-3 4-amino-9-methoxy-7H-furo<3,2-g><1>benzopyran-7-one 

Downstream Products

• 7494-70-4 2,3,4-trichloro-9-methoxy-2,3-dihydro-furo[3,2-g]chromen-7-one 

Relevant articles and documents

Efficient halogenation synthesis method of aryl halide

The invention discloses an efficient halogenation synthesis method of aryl halide. The method comprises the following step: in the presence of a catalyst (sulfoxide or oxynitride), a halogenation reagent and a solvent, carrying out a halogenation reaction on an aromatic ring compound to obtain the aryl halide. According to the present invention, in the presence of a catalyst (sulfoxide or nitrogenoxide), a halogenation reagent and a solvent, the aromatic ring is subjected to an efficient halogenation reaction, such that the very useful aryl halide can be obtained with high activity and high selectivity; and by adopting the method disclosed by the invention, aryl halides can be efficiently synthesized, and the method has a wide application prospect in actual production.

Structural modification of a specific antimicrobial lead against Helicobacter pylori discovered from traditional Chinese medicine and a structure-activity relationship study

Psoralen (1a) was found to be a specific and potent antimicrobial lead against Helicobacter pylori (H. pylori) from a traditional Chinese medicine (TCM) in the bioassay directed isolation. A series of structurally diverse analogues of 1a were thus designed and synthesized to improve the antimicrobial potency, some of which showed more potent activities than the lead compound (1a) against H. pylori. Among them, compound 25a is 16-fold stronger (MIC = 0.39 μg/mL) than 1a (MIC = 6.25 μg/mL), and is even potent than the positive control metronidazole (MIC = 0.50 μg/mL). The in vitro antimicrobial activities against H. pylori of these structurally diverse analogues based on the scaffold of 1a have also led to an outline of structure-activity relationship.