7474-65-9

Basic information

• Product Name: (2E)-1,2,3-triphenylprop-2-en-1-one
• Synonyms: (2E)-1,2,3-Triphenylprop-2-en-1-one; 1,2,3-Triphenyl-2-propen-1-one; 2-propen-1-one, 1,2,3-triphenyl-, (2E)-
• CAS NO: 7474-65-9
• Molecular Formula: C₂₁H₁₆O
• Molecular Weight: 284.3511
• Mol File: 7474-65-9.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 432.7°C at 760 mmHg
• Flash Point: 188.9°C
• Density: 1.128g/cm³
• Vapor Pressure: 1.09E-07mmHg at 25°C
• Refractive Index: 1.65
• CAS DataBase Reference: (2E)-1,2,3-triphenylprop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-1,2,3-triphenylprop-2-en-1-one(7474-65-9)
• EPA Substance Registry System: (2E)-1,2,3-triphenylprop-2-en-1-one(7474-65-9)

Safety Data

• Hazardous Substances Data: 7474-65-9(Hazardous Substances Data)

Usage

Description

(2E)-1,2,3-triphenylprop-2-en-1-one, commonly known as chalcone, is a chemical compound characterized by its molecular formula C21H16O. It presents as a yellow crystalline solid with a distinctive sweet aroma. Chalcone is recognized for its diverse reactivity, making it a key precursor in the synthesis of pharmaceuticals, agrochemicals, and dyes. Its potential biological activities, such as antioxidant, anti-inflammatory, and anti-cancer properties, further establish its significance in medicinal and pharmaceutical fields. Moreover, chalcone's potent fluorescent properties have garnered it a prominent role in fluorescence spectroscopy and imaging.

Uses

Used in Pharmaceutical Industry:
Chalcone serves as a crucial intermediate in the synthesis of various pharmaceuticals, leveraging its versatile reactivity to produce a wide array of medicinal compounds.
Used in Agrochemical Industry:
In the agrochemical sector, chalcone is utilized as a precursor for the development of different agrochemicals, contributing to its broad application in agriculture.
Used in Dye Industry:
Chalcone's role as a precursor extends to the dye industry, where it is instrumental in the creation of a variety of dyes.
Used in Medicinal Applications:
Chalcone is employed for its biological activities, such as its antioxidant, anti-inflammatory, and anti-cancer properties, making it a valuable asset in the formulation of medicinal products.
Used in Fluorescence Spectroscopy and Imaging:
Capitalizing on its potent fluorescent characteristics, chalcone finds numerous applications in the field of fluorescence spectroscopy and imaging, aiding in research and diagnostic procedures.

Upstream product

• 39672-25-8 3-azido-1,2,3-triphenylcyclopropene 
• 4842-45-9 1,2,3-triphenylpropan-1-one 
• 93321-44-9 1,3-diphenylprop-2-yn-1-yl acetate 
• 98-80-6 phenylboronic acid 
• 591-50-4 iodobenzene 
• 2042-85-5 1,2-diphenylpropan-1-one 
• 4452-11-3 1,2-diphenylprop-2-en-1-one 
• 50-00-0 formaldehyd 
• 501-65-5 diphenyl acetylene 
• 451-40-1 phenyl benzyl ketone 
• 103-49-1 dibenzylamine 
• 100-52-7 benzaldehyde 
• 1005501-69-8 3-diazo-4-phenyl-2-butanone 
• 134-81-6 benzil 

Downstream Products

• 7474-64-8 cis-2,3-diphenyl-2,3-dihydro-1H-inden-1-one 
• 7474-64-8 (2RS,3RS)-2-phenyl-3-phenyl-2,3-dihydro-1H-inden-1-one 
• 7512-67-6 (Z)-1,2,3-triphenyl-2-propen-1-one 
• 94348-26-2 (E)-1-(p-methoxyphenyl)-2,3-diphenyl-2-propen-1-one 
• 94348-27-3 (Z)-1-(4-methoxyphenyl)-2,3-diphenylprop-2-en-1-one 
• 109242-28-6 (+/-)-1.2t_F.3-triphenyl-propanol-(1r_F) 
• 1380076-98-1 (S)-2-amino-4,5,6-triphenyl-4H-pyran-3-carbonitrile 
• 1380077-07-5 (R)-2-amino-4,5,6-triphenyl-4H-pyran-3-carbonitrile 
• 1380077-06-4 (S)-ethyl 2-amino-4,5,6-triphenyl-4H-pyran-3-carboxylate 
• 495395-77-2 (2R)-1,2,3-triphenyl-propan-1-one 
• 7476-12-2 phenyl 1,3,3-triphenylprop-2-enyl ketone 
• 42177-21-9 3-hydroxy-1.1.2.3-tetraphenyl-propane 
• 38274-35-0 1,2,3-triphenylindene 
• 50517-67-4 1,3,3-triphenyl-1,2-propanedione 

Relevant articles and documents

Method for synthesizing alpha, beta unsaturated ketone

The invention belongs to the technical field of chemical synthesis, and particularly relates to a method for synthesizing alpha, beta unsaturated ketone. The reaction adopts a synergetic catalysis system of Co(acac)2 or Co(acac)3, a ligand and AlMe3, provides a way for economically and selectively synthesizing alpha, beta unsaturated ketones by atoms, and has the advantages of high yield and wide substrate range.

Heterogeneous gold-catalyzed oxidative cross-coupling of propargylic acetates with arylboronic acids leading to (E)-α-arylenones

An efficient heterogeneous gold-catalyzed oxidative cross-coupling of propargylic acetates with arylboronic acids has been developed that proceeds smoothly in the presence of Selectfluor and provides a general and powerful tool for the preparation of various valuable α-arylenones with moderate to good yields, excellent E-selectivity, and recyclability of the gold catalyst. The reaction is the first example of heterogeneous gold-catalyzed arylative rearrangement of propargylic acetates for construction of complex enones.

Rhodium(I)-catalyzed carbonylative arylation of alkynes with arylboronic acids using formaldehyde as a carbonyl source

The rhodium(I)-catalyzed reaction of alkynes with arylboronic acids in the presence of formaldehyde resulted in a carbon monoxide gas-free carbonylative arylation to yield α,β-enones. The simultaneous loading of phosphine-ligated and phosphine-free rhodium(I) complexes is required for efficient catalysis, which catalyze the abstraction of a carbonyl moiety from formaldehyde (decarbonylation) and its subsequent introduction into the substrate (carbonylation), respectively. Georg Thieme Verlag Stuttgart New York.