74788-46-8

Basic information

• Product Name: 1-(4-CHLOROPHENYL)PROPAN-1-AMINE
• Synonyms: 1-(4-CHLOROPHENYL)PROPAN-1-AMINE;1-(4-chlorophenyl)propan-1-amine(SALTDATA: FREE);1-(4-chlorophenyl)propylamine
• CAS NO: 74788-46-8
• Molecular Formula: C₉H₁₂ClN
• Molecular Weight: 169.65128
• Mol File: 74788-46-8.mol
• Article Data: 8

Chemical Properties

• Melting Point: 67-68 °C
• Boiling Point: 244.317°C at 760 mmHg
• Flash Point: 117.062°C
• Appearance: /
• Density: 1.094g/cm³
• Vapor Pressure: 0.031mmHg at 25°C
• Refractive Index: 1.543
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 9.13±0.10(Predicted)
• CAS DataBase Reference: 1-(4-CHLOROPHENYL)PROPAN-1-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-CHLOROPHENYL)PROPAN-1-AMINE(74788-46-8)
• EPA Substance Registry System: 1-(4-CHLOROPHENYL)PROPAN-1-AMINE(74788-46-8)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 74788-46-8(Hazardous Substances Data)

Usage

General Description

1-(4-chlorophenyl)propan-1-amine is a chemical compound with the molecular formula C9H12ClN. It is also known by its common name, para-Chloroamphetamine (PCA). This chemical is a derivative of amphetamine and is a psychoactive drug with stimulant effects on the central nervous system. It has been used in scientific research to study the neurochemistry and pharmacology of neurotransmitters such as serotonin and dopamine. PCA is also known to have potential neurotoxic effects and is regulated as a controlled substance in many countries due to its abuse potential.

InChI:InChI=1/C9H12ClN/c1-2-9(11)7-3-5-8(10)6-4-7/h3-6,9H,2,11H2,1H3

Upstream product

• 6285-05-8 4'-chloropropiophenone 
• 540-69-2 ammonium formate 
• 925-90-6 ethylmagnesium bromide 
• 85654-07-5 N-(4-chlorobenzylidene)-N-(1,1,1-trimethylsilyl)amine 
• 56962-09-5 1-(4-chlorophenyl)-N-hydroxypropan-1-imine 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 1143532-27-7 4-amino-N-(1-(4-chlorophenyl)propyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide 
• 132361-85-4 (Z)-3-[1-(4-Chloro-phenyl)-propylamino]-but-2-enoic acid methylamide 
• 74787-93-2 3-[1-(4-Chloro-phenyl)-propyl]-1-(2-hydroxy-ethyl)-1-methyl-thiourea 

Relevant articles and documents

MODULATORS OF HSD17B13 AND METHODS OF USE THEREOF

The disclosure relates to compounds and pharmaceutical compositions capable of modulating the hydroxysteroid 17-beta dehydrogenase (HSD17B) family member proteins including inhibiting the HSD17B member proteins, e.g. HSD17B13. The disclosure further relates to methods of treating liver diseases, disorders, or conditions with the compounds and pharmaceutical compositions disclosed herein, in which the HSD17B family member protein plays a role.

Substituent effects on chiral resolutions of derivatized 1-phenylalkylamines by heptakis(2,3-di-O-methyl-6-O-tert-butyldimethylsilyl)-β-cyclodextrin GC stationary phase

Chiral resolutions of trifluoroacetyl-derivatized 1-phenylalkylamines with different type and position of substituent were investigated by capillary gas chromatography by using heptakis(2,3-di-O-methyl-6-O-tert-butyldimethylsilyl)-β-cyclodextrin diluted in OV-1701 as a chiral stationary phase. The influence of column temperature on retention and enantioselectivity was examined. All enantiomers of meta-substituted analytes as well as fluoro-substituted analytes could be resolved. Temperature had a favorable influence on enantioselectivity for small amines with substituents at the ortho-position. The type of substituent at the stereogenic center of amines also had a crucial effect as the ethyl group led to poor enantioseparation. Among all analytes studied, trifluoroacetyl-derivatized 1-(2′-fluorophenyl)ethylamine exhibited baseline resolution with the shortest analysis time.

PROCESS FOR THE PREPARATION OF CHIRAL AMINES FROM PROCHIRAL KETONES

There is provided a method for the preparation of an enantiomerically enriched amine from a prochiral ketone.