7494-45-3

Basic information

• Product Name: 4,5-DICHLORO-2-NITROTOLUENE
• Synonyms: 4,5-DICHLORO-2-NITROTOLUENE;1,2-DICHLORO-4-METHYL-5-NITRO-BENZENE;4,5-Dichloro-2-Methylnitrobenzene;7494-45-3;Benzene, 1,2-dichloro-4-methyl-5-nitro-
• CAS NO: 7494-45-3
• Molecular Formula: C₇H₅Cl₂NO₂
• Molecular Weight: 206.03
• Mol File: 7494-45-3.mol
• Article Data: 8

Chemical Properties

• Melting Point: 62 °C
• Boiling Point: 277.1 °C at 760 mmHg
• Flash Point: 121.4 °C
• Appearance: /
• Density: 1.456 g/cm³
• Vapor Pressure: 0.00778mmHg at 25°C
• Refractive Index: 1.585
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• CAS DataBase Reference: 4,5-DICHLORO-2-NITROTOLUENE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-DICHLORO-2-NITROTOLUENE(7494-45-3)
• EPA Substance Registry System: 4,5-DICHLORO-2-NITROTOLUENE(7494-45-3)

Safety Data

• Hazardous Substances Data: 7494-45-3(Hazardous Substances Data)

Usage

Uses

3,4-Dichloro-6-nitrotoluene is used as a reagent in the synthesis of N-hydroxyindole-2-carboxylates as inhibitors of lactate dehydrogenase against cancer cell proliferation. 3,4-Dichloro-6-nitrotoluene is also used in the preparation of polyhalogenated quinoline C-nucleosides as potential antiviral agents.This compound is suitable for lactate dehydrogenase (LDH) related research.

InChI:InChI=1/C7H5Cl2NO2/c1-4-2-5(8)6(9)3-7(4)10(11)12/h2-3H,1H3

Upstream product

• 89-69-0 2,4,5-Trichloronitrobenzene 
• 996-82-7 sodium diethylmalonate 
• 95-75-0 3,4-Dichlorotoluene 
• 70902-72-6 2-chloro-5-methyl-4-nitroaniline 
• 70343-10-1 2,5-dinitro-4-methylaniline 

Downstream Products

• 62492-45-9 2-nitro-4-chloro-5-methoxymethylbenzene 
• 2387-08-8 4,5-or4,6-dichloro-2-amino-toluene 
• 2011-09-8 4,5-dichloro-2-nitrobenzoic acid 
• 121859-57-2 5,6-dichloro-1H-indole 
• 180868-81-9 ethyl α-oxo-3-(2-nitro-4,5-dichlorophenyl)propanoate 
• 548448-68-6 (4,5-dichloro-2-nitrobenzyl)triphenylphosphorane 
• 548448-70-0 (Z)-6-O-(tert-butyldimethylsilyl)-1-(4,5-dichloro-2-nitrophenyl)-1,2-dideoxy-3,4-O-isopropylidene-D-allo-1-enitol 
• 548448-72-2 (E)-6-O-(tert-butyldimethylsilyl)-1-(4,5-dichloro-2-nitrophenyl)-1,2-dideoxy-3,4-O-isopropylidene-D-allo-1-enitol 
• 138992-15-1 dimethyl 2-(2-amino-4,5-dichlorophenyl)-1-<4-(methylimidazo<4,5-c>pyrid-1-yl)phenyl>ethylmalonate 
• 439612-43-8 5-(2-chloro-6-methyl-4-nitrophenoxy)-3-isopropyl-1H-indole 
• 1093098-01-1 C₁₄H₉ClFNO₃ 
• 1093097-87-0 C₁₄H₈Cl₂FNO₃ 
• 1093097-91-6 C₁₄H₈Cl₃NO₃ 
• 875664-57-6 4,5-difluoro-2-methylaniline 

Relevant articles and documents

Preparation method of dichlorotoluene nitride intermediate

The invention belongs to the technical field of preparation of pesticide intermediates, and particularly discloses a preparation method of a dichlorotoluene nitride intermediate. The preparation method comprises the following steps: fully reacting raw materials, a solvent and a nitration reagent to obtain a dichlorotoluene nitride intermediate, wherein the raw materials comprise any one of o-dichlorotoluene, m-dichlorotoluene and p-dichlorotoluene; the solvent is dichloroethane; the nitration reagent is concentrated nitric acid; the dichlorotoluene nitride intermediate is shown as a chemical formula 7 and a chemical formula 12. The preparation method has the advantages that the corrosion to reaction equipment is less, and the generation and discharge of waste acid and waste salt in the production process are greatly reduced.

Synthesis and structure-activity relationships of a series of substituted 2-(1H-furo[2,3-g]indazol-1-yl)ethylamine derivatives as 5-HT2C receptor agonists

A series of novel indazole derivatives were synthesized, and their structure-activity relationships examined in order to identify potent and selective 5-HT2C receptor agonists. Among these compounds, (S)-2-(7-ethyl-1H-furo[2,3-g]indazol-1-yl)-1-methylethylamine (YM348) had a good in vitro profile, that is, high agonistic activity to the human 5-HT2C receptor subtype (EC50 = 1.0 nM) and high selectivity over 5-HT2A receptors. This compound was also effective in a rat penile erection model when administered po.

CYCLIC AMIDINES USEFUL AS NMDA NR2B ANTAGONISTS

The invention encompasses novel compounds of Formula I as well as a method of treating NMDA mediated diseases comprising administration to a patient in need of such treatment a non-toxic amount of a compound of Formula I effective to block the NMDA NR2B r