7494-77-1

Basic information

• Product Name: 4-(DIMETHYLAMINO)BENZHYDROL
• Synonyms: 4-(DIMETHYLAMINO)BENZHYDROL;[4-(DIMETHYLAMINO)PHENYL](PHENYL)METHANOL
• CAS NO: 7494-77-1
• Molecular Formula: C₁₅H₁₇NO
• Molecular Weight: 227.3
• Mol File: 7494-77-1.mol
• Article Data: 19

Chemical Properties

• Melting Point: 66-67°C
• Boiling Point: 386.4°Cat760mmHg
• Flash Point: 197.4°C
• Appearance: /
• Density: 1.108g/cm³
• Vapor Pressure: 1.16E-06mmHg at 25°C
• Refractive Index: 1.613
• CAS DataBase Reference: 4-(DIMETHYLAMINO)BENZHYDROL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(DIMETHYLAMINO)BENZHYDROL(7494-77-1)
• EPA Substance Registry System: 4-(DIMETHYLAMINO)BENZHYDROL(7494-77-1)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 7494-77-1(Hazardous Substances Data)

Usage

General Description

4-(dimethylamino)benzhydrol, also known as benzhydrol dimethylamino derivative, is a chemical compound with the molecular formula C14H17NO. It is a white solid with a melting point of 87-89°C and is soluble in most organic solvents. 4-(dimethylamino)benzhydrol is commonly used in the synthesis of pharmaceuticals and is also utilized as an intermediate in the production of dyes and other organic compounds. It is known for its mild aromatic odor and is considered to have low toxicity. This chemical has potential applications in the pharmaceutical, cosmetic, and dye industries due to its versatile chemical properties.

InChI:InChI=1/C15H17NO/c1-16(2)14-10-8-13(9-11-14)15(17)12-6-4-3-5-7-12/h3-11,15,17H,1-2H3

Upstream product

• 60-29-7 diethyl ether 
• 100-10-7 4-dimethylamino-benzaldehyde 
• 100-52-7 benzaldehyde 
• 108-86-1 bromobenzene 
• 108-90-7 chlorobenzene 
• 603-76-9 1-methylindole 
• 591-51-5 phenyllithium 
• 586-77-6 4-bromo-N,N-dimethylaniline 
• 576-83-0 2,4,6-trimethylphenyl bromide 
• 100-58-3 phenylmagnesium bromide 
• 1623-99-0 phenyl sodium 
• 98-80-6 phenylboronic acid 
• 934-56-5 trimethyl(phenyl)stannane 
• 7647-01-0 hydrogenchloride 

Downstream Products

• 88103-87-1 N,N-dimethyl-4-[α-(toluene-4-sulfonyl)-benzyl]-aniline 
• 586-77-6 4-bromo-N,N-dimethylaniline 
• 108618-62-8 4-(amino(phenyl)methyl)-N,N-dimethylaniline 
• 129-73-7 bis(4-dimethylaminophenyl)phenylmethane 
• 21571-75-5 N,N-dimethyl-4-(α-p-tolylsulfanyl-benzyl)-aniline 
• 100-52-7 benzaldehyde 
• 138-89-6 p-dimethylaminonitrosobenzene 
• 46734-13-8 N,N-dimethyl-4-(phenylmethyl)benzenamine 
• 1562305-95-6 bis[(4-dimethylaminophenyl)phenylmethyl] ether 
• 1562305-77-4 (4-dimethylaminophenyl)(2,4,5-trimethoxyphenyl)phenylmethane 
• 159334-91-5 (4-dimethylaminophenyl)(2-pyrrolyl)phenylmethane 
• 159334-92-6 2,5-bis[(4-dimethylaminophenyl)phenylmethyl]pyrrole 
• 1629958-87-7 C₁₈H₂₁NO 
• 1629958-86-6 C₁₈H₂₁NO 

Relevant articles and documents

Nickel-Mediated Enantiospecific Silylation via Benzylic C-OMe Bond Cleavage

Benzylic stereocenters are found in bioactive and drug molecules, as enantiopure benzylic alcohols have been used to build such a stereogenic center, but are limited to the construction of a C-C bond. Silylation of alkyl alcohols has the potential to build bioactive molecules and building blocks; however, the development of such a process is challenging and unknown. Herein, we describe an unprecedented AgF-assisted nickel catalysis in the enantiospecific silylation of benzylic ethers.

Diarylmethanols synthesis by nickel(II)-catalyzed addition of arylboronic acids to aryl aldehydes

A practical procedure for the addition of arylboronic acids to aromatic aldehydes has been developed in the presence of NiCl2(PPh3)2/1,3-bis-(2,6-diisopropylphenyl)imidazolium chloride (IPr·HCl) system with good yield. Generally, electron-rich and-neutral aryl aldehydes showed excellent reactivity and provided desired products in high yields. This procedure will provide new way to the synthesis of diarylmethanols.

Di(hetero)arylmethanol compound preparation method

The invention belongs to the field of organic synthesis, and particularly relates to a di(hetero)arylmethanol compound preparation method, wherein the di(hetero)arylmethanol compound is prepared in ahigh-yield manner by using commercially available (hetero)aryl aldehyde and commercially available (hetero)arylboronic acid as raw materials and using a cheap and stable divalent nickel source as a catalyst. According to the present invention, the method improves the shortcomings of harsh reaction conditions, more side reactions, difficult post-treatment and the like caused by the general use of metal reagents, avoids the defects of high cost of catalytic reactions of noble metals such as palladium and the like and difficulty in mass production, has characteristics of mild conditions, convenient operation, low cost, high efficiency and environmental friendliness, and is suitable for practical scale production.