Xi:Irritant;
75-11-6Relevant articles and documents
Stone
, p. 112 (1932)
Thermochemical study of the liquid phase equilibrium reaction of dihalomethanes by NMR spectroscopy
Dávalos,Lago,Baer, Tomas
, p. 230 - 234 (2007/10/03)
The liquid phase equilibrium reaction of dihalomethanes (2CH2BrI ? CH2Br2 + CH2I2) has been investigated by NMR spectroscopy, as a function of the temperature and initial concentration of the reactants. The equilibrium constants have been experimentally determined for this reaction from the profile of the NMR spectra. Heat capacity measurements were carried out in the temperature range from 293.15 to 353.15 K by differential scanning calorimetry. The results relate the heats of formation of the three compounds and confirm the recently determined heat of formation of CH2I2 of 107.5 kJ mol-1.
Quinuclidine compounds and drugs containing the same as the active ingredient
-
, (2008/06/13)
The present invention provides an excellent squalene synthesizing enzyme inhibitor. Specifically, it provides a compound (I) represented by the following formula, a salt thereof or a hydrate of them. In which R1 represents (1) hydrogen atom or (2) hydroxyl group; HAr represents an aromatic heterocycle which may be substituted with 1 to 3 groups; Ar represents an optionally substituted aromatic ring; W represents a chain represented by (1) —CH2—CH2— which may be substituted, (2) —CH=CH— which may be substituted, (3) —C≡C—, (4) —NH—CO—, (5) —CO—NH—, (6) —NH—CH2—, (7) —CH2—NH—, (8) —CH2—CO—, (9) —CO—CH2—, (10) —NH—S(O)l—, (11) —S(O)l—NH—, (12) —CH2—S(O)— or (13) —S(O)l—CH2— (l denotes 0, 1 or 2); and X represents a chain represented by (1) a single bond, (2) an optionally substituted C1-6 alkylene chain, (3) an optionally substituted C2-6 alkenylene chain, (4) an optionally substituted C2-6 alkynylene chain, (5) a formula —Q— (wherein Q represents oxygen atom, sulfur atom, CO or N(R2) (wherein R2 represents a C1-6 alkyl group or a C1-6 alkoxy group)), (6) —NH—CO—, (7) —CO—NH—, (8) —NH—CH2—, (9) —CH2—NH—, (10) —CH2—CO—, (11) —CO—CH2—, (12) —NH—S(O)m—, (13) —S(O)m—NH—, (14) —CH2—S(O)m—, (15) —S(O)m—CH2— (wherein m denotes 0, 1 or 2) or (16) —(CH2)n—O— (wherein n denotes an integer from 1 to 6).
