75-86-5Relevant articles and documents
A safe production method for acetone cyanohydrin
Heugebaert, Thomas S.A.,Roman, Bart I.,De Blieck, Ann,Stevens, Christian V.
, p. 4189 - 4191 (2010)
An easily amenable method is presented to produce acetone cyanohydrin on mole scale (output 39 g/h), using a continuous flow system to overcome the high risks associated with the large-scale use of hydrogen cyanide.
DEUTERATED COMPOUNDS FOR TREATING HEMATOLOGIC MALIGNANCIES, AND COMPOSITIONS AND METHODS THEREOF
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Paragraph 00113; 00114, (2017/05/10)
The invention provides novel chemical compounds useful for treating various hematologic malignancies, or a related disease or disorder thereof, and pharmaceutical composition and methods of preparation and use thereof.
Metal bridging for directing and accelerating electron transfer as exemplified by harnessing the reactivity of AIBN
Xie, Yinjun,Guo, Shengmei,Wu, Longmin,Xia, Chungu,Huang, Hanmin
supporting information, p. 5900 - 5904 (2015/05/13)
A new strategy for tuning the electron transfer between radicals and enolates has been developed. This method elicits the innate reactivity of AIBN with a copper catalyst and enables a cascade reaction with cinnamic acids. Electron paramagnetic resonance studies and control experiments indicate that the redox-active copper species not only activates the radical by coordination, but also serves as a bridge to bring the radical and nucleophile within close proximity to facilitate electron transfer. By exploiting possible combinations of redox-active metals and radical entities with suitable coordinating functional groups, this strategy should contribute to the development of a broad range of radical-based reactions.
Synthesis and evaluation of anti-inflammatory and antitussive activity of hydantion derivatives
Lu, Haibin,Kong, Dejuan,Wu, Bin,Wang, Shihan,Wang, Yongsheng
experimental part, p. 638 - 642 (2012/08/28)
1-Methylhydantion is a compound, which was isolated from Oviductus Ranae for the first time. In our study, we found that it showed good antitussive and anti-inflammatory activity. It is also the first report which illustrates the antitussive activity of hydantion derivative. A series of hydantion derivatives were synthesized and evaluated for their anti-inflammatory and antitussive activity in vivo. The pharmacological tests showed that compounds 7a, 7c and 7d have good anti-inflammatory and antitussive activity compared to Ibuprofen and codeine. Compound 7a in particular showed two-fold stronger anti-inflammatory activity than Ibuprofen.