7508-04-5

Basic information

• Product Name: 5-(4-methoxyphenyl)pentanoic acid
• Synonyms: 5-(4-methoxyphenyl)pentanoic acid
• CAS NO: 7508-04-5
• Molecular Formula: C₁₂H₁₆O₃
• Molecular Weight: 208.25364
• Mol File: 7508-04-5.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 371.5°Cat760mmHg
• Flash Point: 142.3°C
• Appearance: /
• Density: 1.093g/cm³
• Vapor Pressure: 3.55E-06mmHg at 25°C
• Refractive Index: 1.52
• CAS DataBase Reference: 5-(4-methoxyphenyl)pentanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-methoxyphenyl)pentanoic acid(7508-04-5)
• EPA Substance Registry System: 5-(4-methoxyphenyl)pentanoic acid(7508-04-5)

Safety Data

• Hazardous Substances Data: 7508-04-5(Hazardous Substances Data)

Usage

General Description

5-(4-methoxyphenyl)pentanoic acid is a chemical compound that is also known as ibuprofen, which is a nonsteroidal anti-inflammatory drug (NSAID) commonly used for its pain-relieving and anti-inflammatory properties. The compound's chemical structure consists of a pentanoic acid chain with a 4-methoxyphenyl group attached at the 5th carbon position, and it acts by inhibiting the synthesis of prostaglandins, which play a role in inflammation, pain, and fever. Ibuprofen is widely used for the treatment of various conditions such as arthritis, headache, menstrual cramps, and fever, and is available in both prescription and over-the-counter forms for oral and topical administration.

InChI:InChI=1/C12H16O3/c1-15-11-8-6-10(7-9-11)4-2-3-5-12(13)14/h6-9H,2-5H2,1H3,(H,13,14)

Upstream product

• 4654-08-4 5-(4'-hydroxyphenyl)pentanoic acid 
• 77-78-1 dimethyl sulfate 
• 854401-87-9 1,10-bis-(4-methoxy-phenyl)-decane-5,6-diol 
• 546-67-8 lead(IV) tetraacetate 
• 71-43-2 benzene 
• 110146-59-3 1,6-bis-(4-methoxy-phenyl)-hex-1-ene 
• 67-64-1 acetone 
• 100-66-3 methoxybenzene 
• 123-11-5 4-methoxy-benzaldehyde 
• 105-13-5 4-Methoxybenzyl alcohol 
• 5406-18-8 3-(p-methoxyphenyl)-1-propanol 
• 124-38-9 carbon dioxide 
• 23002-61-1 1-(4-chlorobutyl)-4-methoxybenzene 
• 15823-04-8 methyl 3-(4-methoxyphenyl)propionate 

Downstream Products

• 34665-81-1 5-hydroxy-5-(4-methoxyphenyl)valeric acid δ lactone 
• 14374-54-0 5-(4-methoxyphenyl)pentan-1-ol 
• 1379005-30-7 (S)-5-(4-methoxyphenyl)-2-methylpentan-1-ol 
• 1379005-31-8 (S)-5-(4-methoxyphenyl)-2-methylpentanal 
• 1379005-32-9 (S)-2-(methoxymethyl)-N-((S)-5-(4-methoxyphenyl)-2-methylpentylidene)pyrrolidin-1-amine 
• 1187780-63-7 (S)-4-benzyl-3-(5-(4-methoxyphenyl)pentanoyl)oxazolidin-2-one 
• 1379005-29-4 (S)-4-benzyl-3-((S)-5-(4-methoxyphenyl)-2-methylpentanoyl)oxazolidin-2-one 
• 1071001-50-7 1,1,1,2,2-pentafluoro-7-(4-methoxyphenyl)heptan-3-one 
• 1847-68-3 5-(4-methoxy-phenyl)-5-oxo-pentanoic acid methyl ester 
• 154044-13-0 ethyl 5-(4-(hydroxyl)phenyl)pentanoate 

Relevant articles and documents

Heterocyclization involving benzylic C(sp3)-H functionalization enabled by visible light photoredox catalysis

A general and efficient method for heterocyclization involving benzylic C(sp3)-H functionalization enabled by visible light photoredox catalysis to access a wide range of structurally diverse oxygen as well as nitrogen heterocycles up to a gram scale is reported. The potential application of this new methodology is demonstrated by the total synthesis of (-)-codonopsinine and (+)-centrolobine. Herein it is proposed that selectfluor, unlike a fluorinating reagent, acts as an oxidative quencher and a hydrogen radical acceptor.

Ni-Catalyzed Carboxylation of Unactivated Alkyl Chlorides with CO2

A catalytic carboxylation of unactivated primary, secondary, and tertiary alkyl chlorides with CO2 at atmospheric pressure is described. This protocol represents the first intermolecular cross-electrophile coupling of unactivated alkyl chlorides, thus leading to new knowledge in the cross-coupling arena.

Ni-catalyzed carboxylation of unactivated primary alkyl bromides and sulfonates with CO2

A Ni-catalyzed carboxylation of unactivated primary alkyl bromides and sulfonates with CO2 at atmospheric pressure is described. The method is characterized by its mild conditions and remarkably wide scope without the need for air- or moisture-sensitive reagents, which make it a user-friendly and operationally simple protocol en route to carboxylic acids.