75092-30-7

Basic information

• Product Name: 4-IODO-1-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID
• Synonyms: 4-IODO-1-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID;4-Iodo-1-methylpyrazole-5-carboxylic Acid;4-iodo-1-methyl-1H-pyrazole-5-carboxylic acid(SALTDATA: FREE);4-Iodo-1-methyl-1H-pyrazole-5-carboxylic acid 98%;5-Carboxy-4-iodo-1-methyl-1H-pyrazole, 4-Iodo-2-methyl-2H-pyrazole-3-carboxylic acid;4-Iodo-1-methyl-1H-pyrazole-5-carboxylicacid98%;4-iodo-2-methylpyrazole-3-carboxylic acid
• CAS NO: 75092-30-7
• Molecular Formula: C₅H₅IN₂O₂
• Molecular Weight: 252.00987
• Product Categories: HFC00039
• Mol File: 75092-30-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 242°C(lit.)
• Boiling Point: 362.2 °C at 760 mmHg
• Flash Point: 172.9 °C
• Appearance: /
• Density: 2.26 g/cm³
• Vapor Pressure: 7E-06mmHg at 25°C
• Refractive Index: 1.726
• Storage Temp.: 2-8°C(protect from light)
• PKA: 1.76±0.37(Predicted)
• CAS DataBase Reference: 4-IODO-1-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-IODO-1-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID(75092-30-7)
• EPA Substance Registry System: 4-IODO-1-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID(75092-30-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 75092-30-7(Hazardous Substances Data)

Usage

General Description

4-IODO-1-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID is a chemical compound with the molecular formula C7H7IN2O2 and a molar mass of 268.05 g/mol. It is a carboxylic acid derivative that contains an iodo and a methyl group attached to a pyrazole ring. 4-IODO-1-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID has been researched for its potential applications in organic synthesis and pharmaceutical development. It may also serve as a building block for the synthesis of other compounds with similar structural motifs. As with any chemical, proper handling and disposal protocols should be followed to ensure safe and responsible use.

InChI:InChI=1/C5H5IN2O2/c1-8-4(5(9)10)3(6)2-7-8/h2H,1H3,(H,9,10)

Upstream product

• 16034-46-1 1-methyl-1H-pyrazole-5-carboxylic acid 
• 1354705-42-2 ethyl 4-iodo-1-methyl-1H-pyrazole-5-carboxylic acid 
• 6647-96-7 4-iodo-1,5-dimethyl-1H-pyrazole 

Downstream Products

• 92534-69-5 1-methyl-4-nitro-1H-pyrazole-5-carboxylic acid 
• 1620074-54-5 C₁₃H₁₄IN₃O₂ 
• 1354705-42-2 ethyl 4-iodo-1-methyl-1H-pyrazole-5-carboxylic acid 

Relevant articles and documents

LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS

Compounds, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds to treat, prevent or diagnose diseases, disorders, or conditions associated with one or more of the lysophosphatidic acid receptors are provided.

Efficient iodination of structurally varying pyrazoles in heterophase medium

A synthesis of 4-iodo-substituted pyrazoles by iodination of pyrazole and its derivatives in the heterophase (H2O/CHCl3 (CCl 4)) medium with the system KI-KIO3 in the presence of H2SO4 additives was accomplished. The yields of 4-iodo-substituted pyrazoles in the iodination of pyrazole, 3,5- dimethylpyrazole, pyrazole-3(5)-carboxylic acid, 1-methylpyrazole-3-carboxylic acid, 1-methylpyrazole-5-carboxylic acid, 3-nitropyrazole, 1-methyl-3- nitropyrazole, 1-methylpyrazole, 1-ethylpyrazole, and 1-isopropylpyrazole were within 80-97%, whereas in the case of 3-nitropyrazole-5-carboxylic acid it was 32%.

OXIDATIVE IODINATION OF SUBSTITUTED N-METHYLPYRAZOLES

-